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Effects of Botulinum Toxin A on an Incisional Hernia Reconstruction in a Rat Model

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Abstract
Background:

Although the effects of botulinum toxin A on hernia reconstruction have been consistently reported, few studies provide objective evidence. The authors aimed to compare the effects of chemical component separation with those of mechanical component separation, and with a combination of chemical and mechanical component separation, in a rat hernia model.

Methods:

Rats were divided into four groups: 1, control; 2, chemical component separation; 3, mechanical component separation; and 4, chemical and mechanical component separation. Four weeks after hernia induction, botulinum toxin A was injected into groups 2 and 4. Hernia repair was performed 2 weeks after chemical component separation when mechanical component separation was performed in groups 3 and 4. Pretreatment and posttreatment defect sizes, traction forces, intraabdominal pressure, and hernia recurrences were analyzed.

Results:

The defect size was significantly decreased in groups 2 and 4 after chemical component separation. The traction force was significantly smaller in groups 2 and 3 compared with the control group, and the effects of chemical and mechanical component separation were additive. The mean intraabdominal pressure was 16.83 mmHg in group 1, 10.67 mmHg in group 2, 10.17 mmHg in group 3, and 9.67 mmHg in group 4, thus showing significant reductions following chemical and mechanical component separation. Recurrence was observed in all six animals (100 percent) in groups 1 and 3, but in only one of six (17 percent) in groups 2 and 4.

Conclusions:

Preoperative botulinum toxin A significantly reduces hernia size (by 30 percent) and the traction force required to medialize the rectus abdominis. After hernia repair, chemical component separation decreases the intraabdominal pressure to a similar degree as mechanical component separation, but only chemical component separation appears to reduce hernia recurrence.
Author(s)
권진근김은기
Issued Date
2021
Type
Article
Keyword
AnimalsBotulinum toxinBotulinum ToxinsType A - administration & dosageCombined Modality TherapyDisease ModelsAnimalHerniaHerniorrhaphy - methodsIncisional Hernia - drug therapyIncisional Hernia - surgeryMaleMedical collegesRatsRatsSprague-DawleyRectus Abdominis - surgerySurgeryPlastic
DOI
10.1097/PRS.0000000000007986
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7558
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2526138973&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Effects%20of%20Botulinum%20Toxin%20A%20on%20an%20Incisional%20Hernia%20Reconstruction%20in%20a%20Rat%20Model&offset=0&pcAvailability=true
Publisher
PLASTIC AND RECONSTRUCTIVE SURGERY
Location
미국
Language
영어
ISSN
0032-1052
Citation Volume
147
Citation Number
6
Citation Start Page
1331
Citation End Page
1341
Appears in Collections:
Medicine > Medicine
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