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Locoregional recurrence following nipple-sparing mastectomy with immediate breast reconstruction: Patterns and prognostic significance

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Abstract
Introduction: There are limited available data on the prognostic implications of locoregional recurrence (LRR) after nipple-sparing mastectomy (NSM) and immediate reconstruction. In this study, we investigated the patterns and prognosis associated with LRR following this treatment approach for breast cancer.

Methods: A total of 1696 patients with primary breast cancer who underwent NSM with immediate reconstruction from March 2003 to December 2016 were retrospectively analyzed. Post-recurrence disease-free survival (DFS) and distant metastasis-free survival (DMFS) rates were calculated using the Kaplan-Meier method and compared using the log-rank test. Univariate and multivariate analyses using the Cox proportional hazards model were performed to evaluate the prognostic factors associated with the DFS and DMFS.

Results: After a median follow-up period of 84 months, we identified 172 patients (10.1%) with an LRR as the first event. The 5-year post-recurrence DFS rates for the nipple-areola complex recurrence (NCR), skin or subcutaneous recurrence/chest wall recurrence (SCR/CWR), and regional recurrence (RR) groups were 89.1%, 73%, and 59.4%, respectively (P = 0.009), and the 5-year post-recurrence DMFS rates for the NCR, SCR/CWR, and RR groups were 96%, 82.8%, and 59.7%, respectively (P < 0.001). In multivariate analysis, a time to LRR <2 years (P = 0.016) and the site of LRR (P = 0.022) were significantly associated with the post-recurrence DFS.

Conclusions: NCR is more likely to be detected as a non-invasive recurrence and is associated with more favorable overall outcomes than other LRR types. The interval to LRR and its site of onset seem to be associated with the prognostic outcomes.

(c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Author(s)
고범석공경엽김성배김지선김학희김희정손병호안세현엄진섭이새별이종원정일용한현호Jing HanZhen-Yu Wu
Issued Date
2021
Type
Article
Keyword
AnalysisBreast cancerDiseasesImmediate breast reconstructionLocoregional recurrenceMammaplastyMetastasisNipple-sparing mastectomyPatternPrognosisRelapse
DOI
10.1016/j.ejso.2021.01.006
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7563
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2481125436&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Locoregional%20recurrence%20following%20nipple-sparing%20mastectomy%20with%20immediate%20breast%20reconstruction:%20Patterns%20and%20prognostic%20significance&amp;offset=0&amp;pcAvailability=true
Publisher
EJSO
Location
영국
Language
영어
ISSN
0748-7983
Citation Volume
47
Citation Number
6
Citation Start Page
1309
Citation End Page
1315
Appears in Collections:
Medicine > Medicine
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