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Association between the lactate/albumin ratio and mortality in pediatric septic shock patients with underlying chronic disease: retrospective pilot study

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Abstract
BACKGROUND: We aimed to evaluate the ability of the lactate/albumin ratio to predict mortality in pediatric septic shock patients.

METHODS: Retrospective analysis of the medical records of a pediatric intensive care unit. The study cohort comprised 90 pediatric septic shock patients admitted from February 2012 to May 2015.

RESULTS: The serum lactate and albumin levels and lactate/albumin ratio were compared between survivors and nonsurvivors. We assessed whether the lactate/albumin ratio could be used to predict mortality. The 28-day hospital mortality was 26.7% (24/90). The lactate level was higher (2.5 +/- 2.2 vs. 8.1 +/- 5.1 mmol/L, P<0.001) and the albumin level was lower (2.9 +/- 0.5 vs. 2.7 +/- 0.5 mg/dL, P=0.063) in non-survivors than in survivors. The lactate/albumin ratio was 0.9 +/- 0.8 in survivors and 3.2 +/- 2.4 in non-survivors (P<0.001). According to the area under the receiver operating characteristic curve (AUC), the lactate/albumin ratio showed good discriminatory power for predicting mortality (AUC=0.867). A lactate/ albumin ratio exceeding 1.016 led to a 7.636-fold increase in mortality.

CONCLUSIONS: The lactate/albumin ratio is a useful predictor of mortality in pediatric septic shock patients.
Author(s)
박성종장원경최승준하은주
Issued Date
2021
Type
Article
Keyword
ShocksepticPediatricsMortalityChronic diseases
DOI
10.23736/S2724-5276.16.04551-5
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7581
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_crossref_primary_10_23736_S2724_5276_16_04551_5&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Association%20between%20the%20lactate%2Falbumin%20ratio%20and%20mortality%20in%20pediatric%20septic%20shock%20patients%20with%20underlying%20chronic%20disease:%20retrospective%20pilot%20study&amp;offset=0&amp;pcAvailability=true
Publisher
MINERVA PEDIATRICS
Location
이탈리아
Language
영어
ISSN
2724-5276
Citation Volume
73
Citation Number
1
Citation Start Page
67
Citation End Page
72
Appears in Collections:
Medicine > Medicine
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