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Neonatal Rotavirus-Associated Leukoencephalopathy Is One of the Main Causes of Fifth-Day Fits

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Abstract
Our province recently experienced an outbreak of neonatal rotavirus-associated leukoencephalopathy. This study aimed to verify whether rotavirus-associated leukoencephalopathy constituted fifth-day fits, which prevailed in Europe and Australia between the 1970s and mid-1980s. Of 118 full-term neonates who were admitted between 2008 and 2017 due to seizures, those who fulfilled the following criteria for fifth-day fits were included: healthy full-term neonates prior to seizures; absence of perinatal asphyxia; seizure onset during 4-6 days of age; and no known cause of neonatal seizures. Overall, 54 patients (45.8%) met the criteria for fifth-day fits. Of them, 44 patients (81.5%) also had rotavirus-associated leukoencephalopathy. The mean annual incidence of fifth-day fits was 5.4 cases, which peaked in 2012-2013 (13 cases) and became zero in 2017. Fifth-day fits with rotavirus-associated leukoencephalopathy accounted for 37.2% of neonatal seizures, which peaked at 70.6% in 2012, and gradually reduced to zero in 2017. Concordance of clinical features between rotavirus-associated leukoencephalopathy and fifth-day fits and their epidemic-like features suggest that rotavirus-associated leukoencephalopathy is one of the main causes of fifth-day fits.
Author(s)
오기원임진아이경연
Issued Date
2021
Type
Article
Keyword
Brain - diagnostic imagingElectroencephalography - methodsFemaleHumansInfantNewbornInfantNewbornDiseasesLeukoencephalopathies - complicationsLeukoencephalopathies - diagnostic imagingLeukoencephalopathies - virologyMagnetic Resonance Imaging - methodsMaleRepublic of KoreaRotavirusRotavirus Infections -complicationsSeizures - etiologySeizures - virology
DOI
10.1177/0883073820975275
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7586
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2466036493&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Neonatal%20Rotavirus-Associated%20Leukoencephalopathy%20Is%20One%20of%20the%20Main%20Causes%20of%20Fifth-Day%20Fits&sortby=rank&pcAvailability=true
Publisher
JOURNAL OF CHILD NEUROLOGY
Location
미국
Language
영어
ISSN
0883-0738
Citation Volume
36
Citation Number
5
Citation Start Page
378
Citation End Page
384
Appears in Collections:
Medicine > Medicine
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