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Interactions Between IL-17 Variants and Streptococcus in the Gut Contribute to the Development of Atopic Dermatitis in Infancy

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Abstract
Purpose: Interleukin (IL)-17 variants and perturbations in the gut microbiota may influence the development of atopic dermatitis (AD). However, unifying principles for variants of host and microbe interaction remains unclear. We sought to investigate whether IL-17 variants and gut microbiota affect the development of AD in infancy.

Methods: Composition of the gut microbiota was analyzed in fecal samples from 99 normal healthy and 61 AD infants at 6 months of age. The associations between total immunoglobulin E (IgE), the scoring atopic dermatitis (SCORAD), short-chain fatty acids, transcriptome and functional profile of the gut measured in these subjects and Streptococcus were analyzed. IL-6 and IL-8 in the human intestinal epithelial cell line (HIEC-6) were measured after stimulation of IL-17 and Streptococcus mitis.

Results: In this study, Streptococcus was enriched in infants with AD and was higher in those with the GA + AA of IL-17 (rs2275913) variant. Streptococcus was positively correlated with IgE and SCORAD in infants with AD and GA + AA of IL-17. Butyrate and valerate were negatively correlated with Streptococcus and were decreased in infants with AD and GA + AA. Bacterial genes for oxidative phosphorylation induced by reduced colonization of Clostridium were decreased compared with normal and GG. In transcriptome analysis, lactate dehydrogenase A-like 6B was higher in infants with AD compared with healthy infants. IL-6 and IL-8 were increased in IL-17 and/or S. mitis-stimulated HIEC-6 cells.

Conclusions: These findings suggest that increased Streptococcus and A allele of IL-17 (rs2275913) may contribute to the pathogenesis of AD via modulation of the immune system in infancy.
Author(s)
강미진이소연박윤미김봉수이민정김정현정선미이승화박민지이은상정성수윤지선조현주이은양송이서동인김경원신윤호안강모홍수종
Issued Date
2021
Type
Article
Keyword
Atopic dermatitisgastrointestinal microbiomeIL-17OriginalStreptococcus
DOI
10.4168/aair.2021.13.3.404
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7600
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7984953&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Interactions%20Between%20IL-17%20Variants%20and%20Streptococcus%20in%20the%20Gut%20Contribute%20to%20the%20Development%20of%20Atopic%20Dermatitis%20in%20Infancy&offset=0&pcAvailability=true
Publisher
ALLERGY ASTHMA IMMUNOLOGY RESEARCH
Location
대한민국
Language
영어
ISSN
2092-7355
Citation Volume
13
Citation Number
3
Citation Start Page
404
Citation End Page
419
Appears in Collections:
Medicine > Medicine
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