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Cerebral and Somatic Oxygen Saturation in Neonates with Congenital Heart Disease before Surgery

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Abstract
Background: We investigated preoperative cerebral (ScO2) and abdominal (StO(2)) regional oxygen saturations according to cardiac diagnosis in neonates with critical CHD, their time trends, and the clinical and biochemical parameters associated with them. Methods: Thirty-seven neonates with a prenatal diagnosis of CHD were included. ScO2 and StO(2) values were continuously evaluated using near-infrared spectroscopy. Measurements were obtained hourly before surgery. A linear mixed effects model was used to assess the effects of time and cardiac diagnosis on regional oxygenation and to explore the contributing factors. Results: Regional oxygenation differed according to cardiac diagnosis (p < 0.001). ScO2 was lowest in the patients with severe atrioventricular valvar regurgitation (AVVR) (48.1 +/- 8.0%). StO(2) tended to be lower than ScO2, and both worsened gradually during the period between birth and surgery. There was also a significant interaction between cardiac diagnosis and time. The factors related to ScO2 were hemoglobin and arterial saturation, whereas no factor was associated with StO(2). Conclusions: Preoperative ScO2 and StO(2) in critical CHD differed according to cardiac diagnosis. ScO2 in the patients with severe AVVR was very low, which may imply cerebral hypoxia. ScO2 gradually decreased, suggesting that the longer the time to surgery, the higher the risk of hypoxic brain injury.
Author(s)
김미진김정아백재숙유정진차슬기
Issued Date
2021
Type
Article
Keyword
cerebral oxygen saturationsomatic oxygen saturationcongenital heart disease
DOI
10.3390/jcm10112455
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7605
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_f8ee42e9be924669b3c850c1452c1c9b&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Cerebral%20and%20Somatic%20Oxygen%20Saturation%20in%20Neonates%20with%20Congenital%20Heart%20Disease%20before%20Surgery&amp;offset=0&amp;pcAvailability=true
Publisher
JOURNAL OF CLINICAL MEDICINE
Location
스위스
Language
영어
ISSN
2077-0383
Citation Volume
10
Citation Number
11
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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