Dog Ownership in Early Life Increased the Risk of Nonatopic Asthma in Children
- Abstract
- Background: It is still debatable whether dog ownership during early childhood is a risk factor for the development of allergic diseases.
Objective: We investigated the association of dog ownership in early life with sensitization and asthma in childhood.
Methods: Data from the Cohort for Childhood Origin of Asthma and Allergic diseases were used to investigate the association between dog ownership at any time from pregnancy to 1 year of age and sensitization to aeroallergens at 3 and 7 years old, bronchial hyperresponsiveness (BHR), and asthma at 7 years old. We analyzed the cytokine levels in cord blood (CB) and indoor environmental measurement concentrations in the mother's residence obtained at 36 weeks of pregnancy.
Results: Sensitization to dogs at age 3 and 7 did not differ between dog ownership and nonownership, but dog ownership during early life decreased the risk of sensitization to aeroallergens at age 7 (aOR = 0.44, 95% CI 0.21-0.90). Dog ownership significantly increased the risk of nonatopic BHR (aOR = 2.86; 95% CI 1.32-6.21). In addition, dog ownership was associated with asthma, especially nonatopic asthma at 7 years old (aOR = 2.73, 95% CI 1.02-7.32; aOR = 7.05, 95% CI 1.85-26.90, respectively). There were no significant differences in the concentrations of IL-13 or interferon-γ in CB or indoor environmental measurements according to dog ownership during pregnancy.
Conclusion: Early-life dog exposure in this birth cohort has been shown to reduce atopy but increase the risk of nonatopic BHR and nonatopic asthma at 7 years old.
- Author(s)
- 박민지; 이소연; 송근백; 이시현; 최길용; 이기원; 정성수; 서동인; 신윤호; 김경원; 안강모; 홍수종
- Issued Date
- 2021
- Type
- Article
- Keyword
- Dogs; Bronchial hyperresponsiveness; Asthma
- DOI
- 10.1159/000516057
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7611
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_karger_primary_516057&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Dog%20Ownership%20in%20Early%20Life%20Increased%20the%20Risk%20of%20Nonatopic%20Asthma%20in%20Children&offset=0&pcAvailability=true
- Publisher
- INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
- Location
- 스위스
- Language
- 영어
- ISSN
- 1018-2438
- Citation Volume
- 182
- Citation Number
- 10
- Citation Start Page
- 980
- Citation End Page
- 988
-
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- Medicine > Medicine
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