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Dog Ownership in Early Life Increased the Risk of Nonatopic Asthma in Children

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Abstract
Background: It is still debatable whether dog ownership during early childhood is a risk factor for the development of allergic diseases.
Objective: We investigated the association of dog ownership in early life with sensitization and asthma in childhood.
Methods: Data from the Cohort for Childhood Origin of Asthma and Allergic diseases were used to investigate the association between dog ownership at any time from pregnancy to 1 year of age and sensitization to aeroallergens at 3 and 7 years old, bronchial hyperresponsiveness (BHR), and asthma at 7 years old. We analyzed the cytokine levels in cord blood (CB) and indoor environmental measurement concentrations in the mother's residence obtained at 36 weeks of pregnancy.
Results: Sensitization to dogs at age 3 and 7 did not differ between dog ownership and nonownership, but dog ownership during early life decreased the risk of sensitization to aeroallergens at age 7 (aOR = 0.44, 95% CI 0.21-0.90). Dog ownership significantly increased the risk of nonatopic BHR (aOR = 2.86; 95% CI 1.32-6.21). In addition, dog ownership was associated with asthma, especially nonatopic asthma at 7 years old (aOR = 2.73, 95% CI 1.02-7.32; aOR = 7.05, 95% CI 1.85-26.90, respectively). There were no significant differences in the concentrations of IL-13 or interferon-γ in CB or indoor environmental measurements according to dog ownership during pregnancy.
Conclusion: Early-life dog exposure in this birth cohort has been shown to reduce atopy but increase the risk of nonatopic BHR and nonatopic asthma at 7 years old.
Author(s)
박민지이소연송근백이시현최길용이기원정성수서동인신윤호김경원안강모홍수종
Issued Date
2021
Type
Article
Keyword
DogsBronchial hyperresponsivenessAsthma
DOI
10.1159/000516057
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7611
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_karger_primary_516057&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Dog%20Ownership%20in%20Early%20Life%20Increased%20the%20Risk%20of%20Nonatopic%20Asthma%20in%20Children&offset=0&pcAvailability=true
Publisher
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
Location
스위스
Language
영어
ISSN
1018-2438
Citation Volume
182
Citation Number
10
Citation Start Page
980
Citation End Page
988
Appears in Collections:
Medicine > Medicine
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