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Effect of early-life antibiotic exposure and IL-13 polymorphism on atopic dermatitis phenotype

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Abstract
Background: Although atopic dermatitis (AD) is associated with certain gene variants, the rapidly increasing incidence of AD suggests that environmental factors contribute to disease development. In this study, we investigated the association of AD incidence and phenotype with antibiotic exposure within 6 months of age, considering the dose administered and genetic risk.
Methods: This study included 1637 children from the COCOA cohort. Pediatric allergists assessed the presence of AD at each visit and obtained information about antibiotic exposure for more than 3 days. IL-13 (rs20541) polymorphism was genotyped by the TaqMan method. We stratified the AD phenotypes into four groups and used multinomial logistic regression models for analysis.
Results: Antibiotic exposure within 6 months of age was found to increase the risk of AD within 3 years of life (aOR = 1.40; 95% CI, 1.09-1.81) in dose-dependent manner. Antibiotic exposure more than twice increased the risk of the early-persistent AD phenotype (aOR = 2.50; 95% CI, 1.35-4.63). There was a weak interaction between genetic polymorphisms and environmental factors on the development of AD (p for interaction = 0.06). Children with the IL-13 (rs20541) GA + AA genotype have a higher risk of the early-persistent AD phenotype when exposed to antibiotics more than twice than those with the IL-13 (rs20541) GG genotype and without exposure to antibiotics (aOR = 4.73; 95% CI, 2.01-11.14).
Conclusion: Antibiotic exposure within 6 months was related to the incidence of early-persistent AD and a dose-dependent increase in the incidence of AD in childhood, whose effect was modified by the IL-13 (rs20541) genotype.
Author(s)
박민지이소연이시현강미진송근백정성수윤지선서동인신윤호김경원안강모홍수종
Issued Date
2021
Type
Article
Keyword
AnalysisAntibacterial agentsatopicAtopic dermatitisdermatitisGenetic aspectsGenetic polymorphismsInterleukinsinterleukin-13Medical researchMedicineExperimentalphenotypepolymorhism
DOI
10.1111/pai.13531
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7612
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_gale_infotracacademiconefile_A677379303&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Effect%20of%20early-life%20antibiotic%20exposure%20and%20IL-13%20polymorphism%20on%20atopic%20dermatitis%20phenotype&offset=0&pcAvailability=true
Publisher
PEDIATRIC ALLERGY AND IMMUNOLOGY
Location
덴마크
Language
영어
ISSN
0905-6157
Citation Volume
32
Citation Number
7
Citation Start Page
1445
Citation End Page
1454
Appears in Collections:
Medicine > Medicine
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