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Pulmonary function of healthy Korean children from three independent birth cohorts: Validation of the Global Lung Function Initiative 2012 equation

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Abstract
Background and Objective Global Lung Function Initiative (GLI) 2012 equations were developed to resolve the age-related disparity in interpreting spirometry results. Local validation of the equation is needed, especially in Northeast Asian children. This study evaluated the GLI equation in Korean children. Methods Spirometry indices (FEV1, FVC, FEV1/FVC, and FEF25%-75%) and clinical information were gathered from three population-based birth cohorts. Predicted GLI reference values and z scores of spirometry results were calculated for 1239 healthy children. The mean, standard deviation of z scores were compared with the expected 0 and 1. Probabilities of falling below the lower limit of normal (LLN) (z score: -1.64) were compared with the expected value 5%. GLI z scores were assessed according to low (<-2), normal (>=-2 and <= 2), and high (>2) BMI z score groups. Results Mean z scores significantly differed from 0 for FEV1/FVC in males (mean [95% confidence interval]: 0.18 [0.08, 0.27]) and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in females (-0.23 [-0.31, -0.15] and -0.26 [-0.36, -0.16], respectively). The standard deviation was larger than 1 for all variables in males and FVC and FEV1/FVC in females. The probability of falling below the LLN was significantly larger than 5% for FEV1 (12.13% [9.64, 14.77]), FVC (15.86% [13.06, 18.81]), and forced expiratory flow at 25%-75% of forced vital capacity (FEF25%-75%) (7.31% [5.29, 9.49]) in males and FVC (11.91% [9.40, 14.60]) in females. FEV1 and FVC z scores increased across low to high body mass index (BMI) groups, and FEV1/FVC decreased from low to high BMI groups. Conclusion GLI equations marginally differ from real-world values, which should be considered by pulmonologists in practice or research.
Author(s)
박지수서동인최윤정안강모김경원신윤호이소연조현주이은장광천권지원선용한우성일윤유숙박강서국명희조화진정혜리김자형김형영정진아유향옥최윤경이정림이용아신청호김병년김조안나이경신임윤희홍윤철홍수종
Issued Date
2021
Type
Article
Keyword
AnalysisAsianBirth CohortChildChildrenFemaleForced Expiratory VolumeGlobal Lung Function InitiativeHumansLungMalereference equationReference ValuesRepublic of KoreaSpirometryStandard deviationVital Capacity
DOI
10.1002/ppul.25622
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7613
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_journals_2574033316&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Pulmonary%20function%20of%20healthy%20Korean%20children%20from%20three%20independent%20birth%20cohorts:%20Validation%20of%20the%20Global%20Lung%20Function%20Initiative%202012%20equation&amp;offset=0&amp;pcAvailability=true
Publisher
PEDIATRIC PULMONOLOGY
Location
미국
Language
영어
ISSN
8755-6863
Citation Volume
56
Citation Number
10
Citation Start Page
3310
Citation End Page
3320
Appears in Collections:
Medicine > Medicine
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