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Mid-pregnancy PM2.5 exposure affects sex-specific growth trajectories via ARRDC3 methylation

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Abstract
Prenatal particulate matter <2.5 mu m (PM2.5) is associated with adverse birth growth. However, the longitudinal growth impacts have been little studied, and no mechanistic relationships have been described. We investigated the association between prenatal PM2.5 exposure and growth trajectories, and the possible role of epigenetics. We enrolled 1313 neonates with PM2.5 data measured by ordinary kriging from the COhort for Childhood Origin of Asthma and allergic diseases, followed up at 1, 3, and 5 years to evaluate growth. Differential DNA methylation and pyrosequencing of cord blood leukocytes was evaluated according to the prenatal PM2.5levels and birth weight (BW). PM2.5exposure during the second trimester (T2) caused the lowest BW in both sexes, further adjusted for indoor PM2.5 levels [female, aOR 1.39 (95% CI 1.05-1.83); male, aOR 1.36 (95% CI 1.04-1.79)]. Bayesian distributed lag models with indoor PM2.5 adjustments revealed a sensitive window for BW effects at 10-26 weeks gestation, but only in females. Latent class mixture models indicated that a persistently low weightfor-height percentile trajectory was more prevalent in the highest PM2.5 exposure quartile at T2 in females, compared to a persistently high trajectory (36.5% vs. 20.3%, P = 0.022). Also, in the females only, the high PMand low BW neonates showed significantly greater ARRDC3 methylation changes. ARRDC3 methylation was also higher only in females with low weight at 5 years of age. Higher fetal PM2.5 exposure during T2 may cause a decreased growth trajectory, especially in females, mediated by ARRDC3 hyper-methylation-associated energy metabolism.
Author(s)
조현주이승화이소연김환철김효빈박민지윤지선정성수양송이이은안강모김경원서동인신윤호원혜성이미영김수현이경주최석주권자영전종관최길용홍수종
Issued Date
2021
Type
Article
Keyword
ARRDC3EpigeneticsGrowthPM2.5Sensitive windowTrajectory
DOI
10.1016/j.envres.2021.111640
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7615
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_crossref_primary_10_1016_j_envres_2021_111640&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Mid-pregnancy%20PM2.5%20exposure%20affects%20sex-specific%20growth%20trajectories%20via%20ARRDC3%20methylation&amp;offset=0
Publisher
ENVIRONMENTAL RESEARCH
Location
미국
Language
영어
ISSN
0013-9351
Citation Volume
200
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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