KLI

Gastrectomy, vitamin B12 supplementation and the risk of Parkinson ? s disease: A nationwide cohort study

Metadata Downloads
Abstract
Introduction: Previous evidence has suggested roles for alpha-synuclein propagation and vitamin B12 (VitB12) deficiency in the pathogenesis of Parkinson's disease (PD). We investigated whether gastric cancer (GC) patients who underwent gastrectomy had a lower risk of PD and whether VitB12 supplementation modified the risk.

Methods: GC patients aged >= 50 years who underwent curative gastrectomy between 2007 and 2012 (n = 72,216) and matched comparison groups (n = 211,389) were identified from the Korean National Health Insurance database. The risks of PD were analyzed by Cox regression.

Results: Compared to their matched comparison groups, GC patients who underwent gastrectomy showed a decreased risk of PD (adjusted HR [aHR] 0.86; 95% confidence interval [CI] 0.75-0.98), but the significance disappeared after further adjustment with smoking and body mass index (BMI). To elaborate, subtotal gastrectomy (STG) was associated with decreased risk of PD (aHR 0.85; 95% CI 0.74-0.99) while total gastrectomy (TG) was not (aHR 0.89; 95% CI 0.66-1.19), although the risk reduction was not significant when further adjusted for smoking and BMI. Among the patients who underwent TG, their risk of PD was markedly lower when they had VitB12 supplementation after surgery (aHR 0.36; 95% CI 0.17-0.76), while the risk was higher when they did not have any (aHR 1.55; 95% CI 1.03-2.32).

Conclusions: GC patients who underwent gastrectomy and received uninterrupted VitB12 supplementation had a decreased incidence of PD. This study provides indirect epidemiological evidence for the potential roles of gastrectomy and VitB12 in the pathogenesis of PD.
Author(s)
최윤진최인영장우영정수민박상현한경도이윤택이동호신동욱
Issued Date
2021
Type
Article
Keyword
AgedCancerEpidemiologyFemaleFollow-Up StudiesGastrectomyGastrectomy - statistics & numerical dataGastric cancer patientsHumansMaleMedical researchMedicineExperimentalMiddle AgedParkinson Disease - epidemiologyParkinson's diseasePreventionRepublic of Korea - epidemiologyRiskStomach Neoplasms -epidemiologyStomach Neoplasms - surgeryVitamin B 12 - administration & dosageVitamins
DOI
10.1016/j.parkreldis.2020.12.026
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7625
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2478772201&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Gastrectomy,%20vitamin%20B12%20supplementation%20and%20the%20risk%20of%20Parkinson%20%3F%20s%20disease:%20A%20nationwide%20cohort%20study&offset=0&pcAvailability=true
Publisher
PARKINSONISM & RELATED DISORDERS
Location
네덜란드
Language
한국어
ISSN
1353-8020
Citation Volume
83
Citation Start Page
15
Citation End Page
21
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.