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Prevalence of cerebrovascular diseases that can cause hemorrhagic stroke in liver transplantation recipients: a 6-year comparative study with 24,681 healthy adults

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Alternative Title
Prevalence of cerebrovascular diseases that can cause hemorrhagic stroke in liver transplantation recipients: a 6-year comparative study with 24,681 healthy adults
Abstract
Background and purpose
Cerebrovascular diseases are a leading cause of mortality after liver transplantation (LT). The prevalence
of potentially hemorrhagic cerebrovascular diseases (HCVDs) that could cause a hemorrhagic stroke in patients with
severe liver diseases has not been reported. We aimed to analyze the underlying prevalence of HCVDs that could lead to
hemorrhagic strokes in LT recipients compared with that in previously healthy controls.
Methods
A retrospective study with 1,920 consecutive LT recipients and 24,681 adults who underwent a health checkup during
the same period was conducted (January 2011?December 2016). The prevalence of cerebral aneurysms (CA), cerebral arteriovenous
malformation (AVM), and cavernous malformation (CM) was evaluated using brain imaging, including computed
tomography angiography, magnetic resonance imaging, magnetic resonance angiography, and digital subtraction angiography.
Results
The prevalence of CA and CM were 3.1% and 0.5%, respectively, in the LT group and 3.8% and 0.4%, respectively, in
the control group. According to the location of the cerebral artery, paraclinoid internal carotid artery aneurysms (odds ratio [OR]
0.440; P = 0.009) had a lower prevalence in LT recipients than in healthy controls. Anterior communicating artery (OR 3.080; P
= 0.002) and superior cerebellar artery (OR 8.767; P = 0.017) aneurysms had a higher prevalence in the LT group than in the
control. The prevalence of AVM was significantly higher in LT recipients (0.26%) than in healthy controls (0.06%).
Conclusion
LT recipients showed a different distribution of CA prevalence according to the locations of the cerebral artery and
had a higher overall prevalence of AVM than previously healthy controls.
Author(s)
정연구이승주박중철안재성문은지박정원박원형
Issued Date
2021
Type
Article
Keyword
Arteriovenous malformationsCerebrovascular disordersIntracranial aneurysmLiver transplantation
DOI
10.1007/s10072-020-04863-y
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7632
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2456420901&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Prevalence%20of%20cerebrovascular%20diseases%20that%20can%20cause%20hemorrhagic%20stroke%20in%20liver%20transplantation%20recipients:%20a%206-year%20comparative%20study%20with%2024,681%20healthy%20adults&offset=0&pcAvailability=true
Publisher
NEUROLOGICAL SCIENCES
Location
이탈리아
Language
영어
ISSN
1590-1874
Citation Volume
42
Citation Number
7
Citation Start Page
2753
Citation End Page
2761
Appears in Collections:
Medicine > Medicine
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