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Prognostic factors for relapse and survival among patients with ocular adnexal lymphoma: validation of the eighth edition of the American Joint Committee on Cancer (AJCC) TNM classification

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Abstract
Background/Aims

To validate the prognostic performance of the American Joint Committee on Cancer (AJCC) eighth edition classification for ocular adnexal lymphoma (OAL).

Methods

We performed a retrospective review of 140 consecutive patients treated for primary OAL between March 2010 and September 2017. Associations between T/N/M categories at presentation and disease-related outcomes, including relapse, progression-free survival (PFS) and overall survival (OS) were evaluated.

Results

Seventy-nine women and 61 men (median age, 52 (range 20-84) years; median follow-up, 57 (range 7-131) months) were included. Histological subtypes included mucosa-associated lymphoid tissue lymphoma (92.1%, n=129), diffuse large B-cell lymphoma (5.0%, n=7), follicular lymphoma (1.4%, n=2) and mantle cell lymphoma (1.4%, n=2). Patients with >= T2 disease had significantly higher risks of overall relapse (unadjusted HR)=4.32, p=0.016), decreased PFS (uHR=5.19, p=0.004) and decreased OS (uHR=9.21, p=0.047). Patients with >= N1 disease had significantly higher risks of overall relapse (uHR=9.17, p<0.001) and decreased PFS (uHR=9.24, p<0.001). M1 disease was significantly associated with higher risks of overall relapse (uHR=3.62, p=0.036), decreased PFS (uHR=5.13, p=0.001) and decreased OS (uHR=9.24, p=0.013). On considering TNM categories as continuous data, the uHRs for per level increase in T, N and M categories were 1.77, 1.83 and 2.30 for overall relapse and 1.72, 1.87 and 2.78 for decreased PFS, respectively (p<0.05 for each comparison).

Conclusion

The T, N and M categories of the AJCC eighth edition classification have prognostic value for relapse and survival among patients with primary OAL. Particularly, nodal/metastatic involvement at presentation indicated less favourable outcome.
Author(s)
권미영이지성이충현윤덕현사호석
Issued Date
2021
Type
Article
Keyword
AdultAged80 and overBiopsyChemotherapyConjunctival Neoplasms - classificationConjunctival Neoplasms - diagnosisConjunctival Neoplasms - mortalityEye Neoplasms - classificationEye Neoplasms - diagnosisEye Neoplasms - mortalityEyelid Neoplasms - classificationEyelid Neoplasms - diagnosisEyelid Neoplasms - mortalityEyes &amp; eyesightFemaleHumansLacrimal Apparatus Diseases - classificationLacrimal Apparatus Diseases - diagnosisLacrimal Apparatus Diseases - mortalityLymphomaLymphoma - classificationLymphoma - diagnosisLymphoma - mortalityLymphomaB-CellMarginal Zone - classificationLymphomaB-CellMarginal Zone - diagnosisLymphomaB-CellMarginal Zone - mortalityLymphomaFollicular - classificationLymphomaFollicular - diagnosisLymphomaFollicular - mortalityLymphomaLarge B-CellDiffuse - classificationLymphomaLarge B-CellDiffuse - diagnosisLymphomaLarge B-CellDiffuse - mortalityLymphomaMantle-Cell - classificationLymphomaMantle-Cell - diagnosisLymphomaMantle-Cell - mortalityMaleMedical Oncology - organization &amp; administrationMedical prognosisMiddle AgedNeoplasm RecurrenceLocal - classificationNeoplasm RecurrenceLocal - diagnosisNeoplasm RecurrenceLocal - mortalityNeoplasm Staging - methodsOphthalmologyOrbital Neoplasms - classificationOrbital Neoplasms - diagnosisOrbital Neoplasms - mortalityPrognosisRadiation therapyRetrospective StudiesSocietiesMedicalSurvival RateYoung Adult
DOI
10.1136/bjophthalmol-2020-315875
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7650
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2394884142&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Prognostic%20factors%20for%20relapse%20and%20survival%20among%20patients%20with%20ocular%20adnexal%20lymphoma:%20validation%20of%20the%20eighth%20edition%20of%20the%20American%20Joint%20Committee%20on%20Cancer%20(AJCC)%20TNM%20classification&amp;offset=0&amp;pcAvailability=true
Publisher
BRITISH JOURNAL OF OPHTHALMOLOGY
Location
영국
Language
영어
ISSN
0007-1161
Citation Volume
105
Citation Number
2
Citation Start Page
279
Citation End Page
284
Appears in Collections:
Medicine > Medicine
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