Prognostic factors for relapse and survival among patients with ocular adnexal lymphoma: validation of the eighth edition of the American Joint Committee on Cancer (AJCC) TNM classification
- Abstract
- Background/Aims
To validate the prognostic performance of the American Joint Committee on Cancer (AJCC) eighth edition classification for ocular adnexal lymphoma (OAL).
Methods
We performed a retrospective review of 140 consecutive patients treated for primary OAL between March 2010 and September 2017. Associations between T/N/M categories at presentation and disease-related outcomes, including relapse, progression-free survival (PFS) and overall survival (OS) were evaluated.
Results
Seventy-nine women and 61 men (median age, 52 (range 20-84) years; median follow-up, 57 (range 7-131) months) were included. Histological subtypes included mucosa-associated lymphoid tissue lymphoma (92.1%, n=129), diffuse large B-cell lymphoma (5.0%, n=7), follicular lymphoma (1.4%, n=2) and mantle cell lymphoma (1.4%, n=2). Patients with >= T2 disease had significantly higher risks of overall relapse (unadjusted HR)=4.32, p=0.016), decreased PFS (uHR=5.19, p=0.004) and decreased OS (uHR=9.21, p=0.047). Patients with >= N1 disease had significantly higher risks of overall relapse (uHR=9.17, p<0.001) and decreased PFS (uHR=9.24, p<0.001). M1 disease was significantly associated with higher risks of overall relapse (uHR=3.62, p=0.036), decreased PFS (uHR=5.13, p=0.001) and decreased OS (uHR=9.24, p=0.013). On considering TNM categories as continuous data, the uHRs for per level increase in T, N and M categories were 1.77, 1.83 and 2.30 for overall relapse and 1.72, 1.87 and 2.78 for decreased PFS, respectively (p<0.05 for each comparison).
Conclusion
The T, N and M categories of the AJCC eighth edition classification have prognostic value for relapse and survival among patients with primary OAL. Particularly, nodal/metastatic involvement at presentation indicated less favourable outcome.
- Author(s)
- 권미영; 이지성; 이충현; 윤덕현; 사호석
- Issued Date
- 2021
- Type
- Article
- Keyword
- Adult; Aged; 80 and over; Biopsy; Chemotherapy; Conjunctival Neoplasms - classification; Conjunctival Neoplasms - diagnosis; Conjunctival Neoplasms - mortality; Eye Neoplasms - classification; Eye Neoplasms - diagnosis; Eye Neoplasms - mortality; Eyelid Neoplasms - classification; Eyelid Neoplasms - diagnosis; Eyelid Neoplasms - mortality; Eyes & eyesight; Female; Humans; Lacrimal Apparatus Diseases - classification; Lacrimal Apparatus Diseases - diagnosis; Lacrimal Apparatus Diseases - mortality; Lymphoma; Lymphoma - classification; Lymphoma - diagnosis; Lymphoma - mortality; Lymphoma; B-Cell; Marginal Zone - classification; Lymphoma; B-Cell; Marginal Zone - diagnosis; Lymphoma; B-Cell; Marginal Zone - mortality; Lymphoma; Follicular - classification; Lymphoma; Follicular - diagnosis; Lymphoma; Follicular - mortality; Lymphoma; Large B-Cell; Diffuse - classification; Lymphoma; Large B-Cell; Diffuse - diagnosis; Lymphoma; Large B-Cell; Diffuse - mortality; Lymphoma; Mantle-Cell - classification; Lymphoma; Mantle-Cell - diagnosis; Lymphoma; Mantle-Cell - mortality; Male; Medical Oncology - organization & administration; Medical prognosis; Middle Aged; Neoplasm Recurrence; Local - classification; Neoplasm Recurrence; Local - diagnosis; Neoplasm Recurrence; Local - mortality; Neoplasm Staging - methods; Ophthalmology; Orbital Neoplasms - classification; Orbital Neoplasms - diagnosis; Orbital Neoplasms - mortality; Prognosis; Radiation therapy; Retrospective Studies; Societies; Medical; Survival Rate; Young Adult
- DOI
- 10.1136/bjophthalmol-2020-315875
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7650
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2394884142&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Prognostic%20factors%20for%20relapse%20and%20survival%20among%20patients%20with%20ocular%20adnexal%20lymphoma:%20validation%20of%20the%20eighth%20edition%20of%20the%20American%20Joint%20Committee%20on%20Cancer%20(AJCC)%20TNM%20classification&offset=0&pcAvailability=true
- Publisher
- BRITISH JOURNAL OF OPHTHALMOLOGY
- Location
- 영국
- Language
- 영어
- ISSN
- 0007-1161
- Citation Volume
- 105
- Citation Number
- 2
- Citation Start Page
- 279
- Citation End Page
- 284
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