Prognostic factors for relapse and survival among patients with ocular adnexal lymphoma: validation of the eighth edition of the American Joint Committee on Cancer (AJCC) TNM classification
To validate the prognostic performance of the American Joint Committee on Cancer (AJCC) eighth edition classification for ocular adnexal lymphoma (OAL).
We performed a retrospective review of 140 consecutive patients treated for primary OAL between March 2010 and September 2017. Associations between T/N/M categories at presentation and disease-related outcomes, including relapse, progression-free survival (PFS) and overall survival (OS) were evaluated.
Seventy-nine women and 61 men (median age, 52 (range 20-84) years; median follow-up, 57 (range 7-131) months) were included. Histological subtypes included mucosa-associated lymphoid tissue lymphoma (92.1%, n=129), diffuse large B-cell lymphoma (5.0%, n=7), follicular lymphoma (1.4%, n=2) and mantle cell lymphoma (1.4%, n=2). Patients with >= T2 disease had significantly higher risks of overall relapse (unadjusted HR)=4.32, p=0.016), decreased PFS (uHR=5.19, p=0.004) and decreased OS (uHR=9.21, p=0.047). Patients with >= N1 disease had significantly higher risks of overall relapse (uHR=9.17, p<0.001) and decreased PFS (uHR=9.24, p<0.001). M1 disease was significantly associated with higher risks of overall relapse (uHR=3.62, p=0.036), decreased PFS (uHR=5.13, p=0.001) and decreased OS (uHR=9.24, p=0.013). On considering TNM categories as continuous data, the uHRs for per level increase in T, N and M categories were 1.77, 1.83 and 2.30 for overall relapse and 1.72, 1.87 and 2.78 for decreased PFS, respectively (p<0.05 for each comparison).
The T, N and M categories of the AJCC eighth edition classification have prognostic value for relapse and survival among patients with primary OAL. Particularly, nodal/metastatic involvement at presentation indicated less favourable outcome.
- 권미영; 이지성; 이충현; 윤덕현; 사호석
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- Adult; Aged; 80 and over; Biopsy; Chemotherapy; Conjunctival Neoplasms - classification; Conjunctival Neoplasms - diagnosis; Conjunctival Neoplasms - mortality; Eye Neoplasms - classification; Eye Neoplasms - diagnosis; Eye Neoplasms - mortality; Eyelid Neoplasms - classification; Eyelid Neoplasms - diagnosis; Eyelid Neoplasms - mortality; Eyes & eyesight; Female; Humans; Lacrimal Apparatus Diseases - classification; Lacrimal Apparatus Diseases - diagnosis; Lacrimal Apparatus Diseases - mortality; Lymphoma; Lymphoma - classification; Lymphoma - diagnosis; Lymphoma - mortality; Lymphoma; B-Cell; Marginal Zone - classification; Lymphoma; B-Cell; Marginal Zone - diagnosis; Lymphoma; B-Cell; Marginal Zone - mortality; Lymphoma; Follicular - classification; Lymphoma; Follicular - diagnosis; Lymphoma; Follicular - mortality; Lymphoma; Large B-Cell; Diffuse - classification; Lymphoma; Large B-Cell; Diffuse - diagnosis; Lymphoma; Large B-Cell; Diffuse - mortality; Lymphoma; Mantle-Cell - classification; Lymphoma; Mantle-Cell - diagnosis; Lymphoma; Mantle-Cell - mortality; Male; Medical Oncology - organization & administration; Medical prognosis; Middle Aged; Neoplasm Recurrence; Local - classification; Neoplasm Recurrence; Local - diagnosis; Neoplasm Recurrence; Local - mortality; Neoplasm Staging - methods; Ophthalmology; Orbital Neoplasms - classification; Orbital Neoplasms - diagnosis; Orbital Neoplasms - mortality; Prognosis; Radiation therapy; Retrospective Studies; Societies; Medical; Survival Rate; Young Adult
- BRITISH JOURNAL OF OPHTHALMOLOGY
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