Changes in the expression of matrix metalloproteinase-9 after intense pulsed light therapy combined with meibomian gland expression in moderate and severe meibomian gland dysfunction
- Abstract
- Purpose: To evaluate the combined effect of intense pulsed light (IPL) therapy and meibomian gland expression on extracellular matrix metalloproteinase-9 (MMP-9) levels and clinical outcomes of moderate and severe meibomian gland dysfunction (MGD) treatment.
Methods: This retrospective study was conducted on 45 eyes of 23 patients with moderate and severe MGD. Each eye underwent three IPL sessions and meibomian gland expression at 2-week intervals. In this study the evaluated parameters included tear film break-up time (TBUT), corneal and conjunctival fluorescein staining scores, biomicroscopic examination of lid margins and meibomian glands, ocular surface disease index (OSDI) questionnaire score, and extracellular MMP-9 levels using the immunoassay device before and two weeks after the last treatment session. Linear mixed model and generalized estimating equations model were used to evaluate possible differences. Results: There were significant improvements in TBUT (P < 0.001), SICCA ocular staining score (P = 0.008), Oxford staining score (P = 0.023), lid margin irregularity (P < 0.001 for upper and lower eyelids), lid thickness (P < 0.001 for upper and lower eyelids), meibomian gland plugging (P = 0.010 and P = 0.012 for upper and lower eyelids), meibum color (P = 0.044 and P < 0.001 for upper and lower eyelids), meibum consistency (P < 0.001 for upper and lower eyelids), MGD grade (P < 0.001), and OSDI questionnaire score (P < 0.001). Incidence of positive results for MMP-9 immunoassay significantly decreased from 84.0% to 56.0% (P = 0.031) after treatment.
Conclusion: In patients with moderate to severe MGD, three sessions of IPL combined with meibomian gland expression improved objective findings, subjective symptoms, meibomian gland function, and MMP-9 immunoassay results. The results support the combination of IPL and meibomian gland expression for treating moderate to severe MGD.
- Author(s)
- 김재용; 문수영; 박소영; 이재혁; 이훈; 정호석; 차흥원; 한예은
- Issued Date
- 2021
- Type
- Article
- Keyword
- Analysis; Eye diseases; Fluorescein; InflammaDry immunoassay device; Intense pulsed light; Matrix metalloproteinase-9; Medical colleges; Meibomian gland dysfunction; Meibomian gland expression; Phototherapy
- DOI
- 10.1016/j.clae.2020.05.008
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7657
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2444387930&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Changes%20in%20the%20expression%20of%20matrix%20metalloproteinase-9%20after%20intense%20pulsed%20light%20therapy%20combined%20with%20meibomian%20gland%20expression%20in%20moderate%20and%20severe%20meibomian%20gland%20dysfunction&offset=0&pcAvailability=true
- Publisher
- CONTACT LENS ANTERIOR EYE
- Location
- 영국
- Language
- 영어
- ISSN
- 1367-0484
- Citation Volume
- 44
- Citation Number
- 3
- Citation Start Page
- 0
- Citation End Page
- 0
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