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Glaucoma as a prognostic factor of central retinal vein occlusion: visual and anatomical outcomes and occurrence of ischaemic central retinal vein occlusion

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Abstract
Purpose: To compare the functional and anatomical outcomes of central retinal vein occlusion (CRVO) according to the presence of glaucoma before the onset of CRVO, and to assess whether pre-existing glaucoma affects the prognosis of CRVO in terms of development and conversion to ischaemic CRVO.

Methods: In this retrospective cohort study, patients with treatment-naive CRVO were enrolled between December 2009 and February 2019. The patients were classified into two groups according to the presence of pre-existing primary open-angle glaucoma at CRVO diagnosis. We reviewed medical records regarding basic demographics, ocular characteristics and treatments. The effects of pre-existing glaucoma on the occurrence of ischaemic CRVO were also investigated using Cox proportional hazard models.

Results: Of 166 eyes from 166 patients, 26 (15.7%) had pre-existing glaucoma. The pre-existing glaucoma group revealed significantly older (69.4 ± 13.3 versus 56.5 ± 15.9) and lower BCVA at baseline (1.06 ± 0.75 versus 0.64 ± 0.58, logMAR) and final visits (1.56 ± 1.35 versus 0.64 ± 0.48, logMAR) (all p < 0.05) than non-glaucomatous group. In terms of perfusion status of CRVO, the glaucoma group showed higher incidence of ischaemic CRVO (30.8% versus 5.3%, p = 0.052) at initial and last visits as well as more disorganization of retinal inner layers (DRIL) at 3 months (76.0% versus 49.6%, p = 0.015). Pre-existing glaucoma (hazard ratio (HR) = 2.141, p = 0.014), lower vision at baseline (HR = 2.071, p = 0.001) and DRIL at 3 months (HR = 2.905, p = 0.011) were significant risk factors for the occurrence of ischaemic CRVO.

Conclusion: In patients with CRVO, pre-existing glaucoma was associated with poorer visual and anatomical outcomes, and played as a significant risk factor for the development and conversion to ischaemic CRVO with lower vision and presence of DRIL at early phase of CRVO.

Keywords: central retinal vein occlusion; glaucoma; ischaemic conversion; lamina cribrosa; optical coherence tomography.
Author(s)
김유나김윤전김중곤박유정신중원윤영희이주용
Issued Date
2021
Type
Article
Keyword
central retinal vein occlusionGlaucomaischaemic conversionlamina cribrosaMedical recordsMedical researchMedicineExperimentaloptical coherence tomographyPrognosisRetinal diseases
DOI
10.1111/aos.14608
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7664
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2455840177&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Glaucoma%20as%20a%20prognostic%20factor%20of%20central%20retinal%20vein%20occlusion:%20visual%20and%20anatomical%20outcomes%20and%20occurrence%20of%20ischaemic%20central%20retinal%20vein%20occlusion&amp;offset=0&amp;pcAvailability=true
Publisher
ACTA OPHTHALMOLOGICA
Location
미국
Language
한국어
ISSN
1755-375X
Citation Volume
99
Citation Number
4
Citation Start Page
e523
Citation End Page
e530
Appears in Collections:
Medicine > Medicine
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