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Relationship between peripapillary vessel density and visual field in glaucoma: a broken-stick model

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Abstract
Background/Aims To determine the tipping point at which peripapillary vessel density (pVD), measured using optical coherence tomography angiography (OCT-A), is associated with detectable visual field (VF) loss in cases of open-angle glaucoma (OAG). Methods Peripapillary retinal nerve fibre layer (pRNFL) thickness and pVD were measured using OCT and OCT-A in 166 healthy participants, those with suspected glaucoma and patients with early-stage OAG. All participants were Koreans. A broken-stick model was used to determine the tipping points below which pRNFL thickness (pRNFLT) or pVD reduction was associated with significant VF loss. The slopes were computed above and below the tipping points for the relationship between pVD, pRNFLT and VF sensitivity (VFS). Results Tipping points were detected for pRNFLT globally and in the inferior and superior quadrants, at which there were significant differences between the slopes above and below the tipping points. The slopes above the tipping points were approximately zero. However, no tipping point was found for pVD in the global area or regional sectors. Conclusion The relationship between pVD and VFS does not show a tipping point. This suggests that the correlation between pVD-VFS may be linear and stronger than that of pRNFLT-VFS, even at the early stage of glaucoma.
Author(s)
국문석송민경신중원원훈제조윤혜
Issued Date
2021
Type
Article
Keyword
GlaucomaRegression analysisSoftwareStatistical analysisVariance analysis
DOI
10.1136/bjophthalmol-2020-315973
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7671
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2434053651&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Relationship%20between%20peripapillary%20vessel%20density%20and%20visual%20field%20in%20glaucoma:%20a%20broken-stick%20model&offset=0&pcAvailability=true
Publisher
BRITISH JOURNAL OF OPHTHALMOLOGY
Location
영국
Language
영어
ISSN
0007-1161
Citation Volume
105
Citation Number
7
Citation Start Page
964
Citation End Page
969
Appears in Collections:
Medicine > Medicine
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