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Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis

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Abstract
Ametropia is reported as a common ophthalmic manifestation in craniosynostosis. We retrospectively compared childhood refractive error and ocular biometric features of fibroblast growth factor receptor (FGFR)-related syndromic craniosynostosis patients with those of non-syndromic craniosynostosis and control subjects. Thirty-six eyes (18 patients) with FGFR-related syndromic craniosynostosis, 76 eyes (38 patients) with non-syndromic craniosynostosis, and 114 eyes (57 patients) of intermittent exotropes were included in the analysis. Mean age at examination was 7.82 +/- 2.51 (range, 4-16) years and mean spherical equivalent was -0.09 +/- 1.46 Diopter. Mean age and refractive error were not different between groups, but syndromic craniosynostosis patients had significantly longer axial length, lower corneal power, and lower lens power than other groups (p<0.01, p<0.01, and p<0.01, respectively). Axial length was positively correlated and keratometry and lens power were negatively correlated with age in non-syndromic craniosynostosis and controls, while these correlations between age and ocular biometric parameters were not present in the FGFR-related syndromic craniosynostosis. In conclusion, ocular biometric parameters in FGFR-related syndromic craniosynostosis differed from those of non-syndromic craniosynostosis and age-matched controls, and did not show the relations with age, suggesting this cohort may have abnormal refractive growth.
Author(s)
이기황이병주임현택정승아
Issued Date
2021
Type
Article
Keyword
CraniosynostosisOcular biometryKeratometryAxial lengthRefraction
DOI
10.1038/s41598-021-85620-9
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7678
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_b45b67fa1ea44e2e9285b04275d75e9b&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Ocular%20biometric%20features%20of%20pediatric%20patients%20with%20fibroblast%20growth%20factor%20receptor-related%20syndromic%20craniosynostosis&amp;offset=0&amp;pcAvailability=true
Publisher
SCIENTIFIC REPORTS
Location
미국
Language
영어
ISSN
2045-2322
Citation Volume
11
Citation Number
1
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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