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Joint association of prenatal bisphenol-A and phthalates exposure with risk of atopic dermatitis in 6-month-old infants.

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Abstract
Background: Prenatal exposure to bisphenol A (BPA) and phthalates could trigger immune response. Few studies have investigated the association between prenatal BPA and phthalate exposure and atopic dermatitis (AD) in infants.
Objective: We aimed to clarify the joint association of prenatal exposure to BPA and phthalate metabolites with AD incidence in 6-month-old infants.
Methods: We included 413 mother-child pairs from theMothers and Children's Environmental Health (MOCEH) in a prospective birth cohort study. Maternal urinary BPA, mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP), and mono-n-butyl phthalate (MnBP) concentrations were measured during early and late pregnancy. We applied the Bayesian kernel machine regression (BKMR) with probit regression to estimate the association of BPA and phthalate metaboliteswith AD incidence after adjusting for potential confounders. Individual association was estimated by differences in predicted probabilities comparing each individual chemical concentration at 75th versus 25th percentiles, while other chemicals were set at their median. Overall joint effect was estimated by differences in predicted probabilities comparing all chemical concentrations at 75th versus 25th percentiles.
Results: Individual effect ofMEHHP in late pregnancywas strongly associatedwith incident AD [Difference: 0.244 (95% credible interval: ?0.066, 0.554)] in the model including both early and late exposures. Furthermore, we confirmed overall joint association of urinary BPA and phthalate metabolites during pregnancy with a higher risk of AD [0.347 (0.168, 0.526) for late pregnancy exposure, and 0.307 (0.094, 0.521) for both early and late pregnancy]. Additionally, the joint association was more prominent among girls than that in boys.
Conclusions: The joint association of prenatal exposure to BPA and phthalates could be associated with the incident AD in 6-month-old infants. Further studies are needed to confirm the synergistic effect of BPA and phthalate exposures on AD in children.
Author(s)
이슬비박성균박혜숙이우주이지현홍윤철하미나김양호이보은하은희
Issued Date
2021
Type
Article
Keyword
Atopic dermatitisBayesian kernel machine regression modelBisphenol AEpoxy resinsEstersInfantsMulti-pollutant effectPhthalatesPregnant womenPrenatal exposureProspective birth cohort
DOI
10.1016/j.scitotenv.2021.147953
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7715
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2556385156&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Joint%20association%20of%20prenatal%20bisphenol-A%20and%20phthalates%20exposure%20with%20risk%20of%20atopic%20dermatitis%20in%206-month-old%20infants.&offset=0&pcAvailability=true
Publisher
SCIENCE OF THE TOTAL ENVIRONMENT
Location
네덜란드
Language
영어
ISSN
0048-9697
Citation Volume
789
Citation Number
1
Citation Start Page
147953
Citation End Page
147953
Appears in Collections:
Medicine > Medicine
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