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Direct and Indirect Effects of Indoor Particulate Matter on Blood Indicators Related to Anemia

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Abstract
Exposure to indoor particulate matter (PM) is a potential risk factor that increases systemic inflammation and affects erythropoiesis. This study investigated the association between exposure to indoor PM and blood indicators related to anemia (BIRA) in housewives. Indoor PM and blood folate status are important factors in the risk of anemia. This was a housewife cohort study; we recruited 284 housewives in Seoul and Ulsan, Republic of Korea. Indoor exposure to PM2.5 and PM10 was measured by gravimetric analysis and sensors. We investigated the BIRA, such as hemoglobin (Hb), hematocrit, mean corpuscular volume (MCV), mean corpuscular Hb (MCH), and mean corpuscular Hb concentration (MCHC). Statistical analysis was performed by multiple linear regression model and mediation analysis. The association between BIRA and PM was assessed by multiple linear regression models fitted by mediation analyses. The increase in the level of indoor PM2.5 was associated with a decrease in MCV (Beta coefficient (B): ??0.069, Standard error (SE): 0.022) and MCH (B: ??0.019, SE: 0.009) in gravimetric measurements. The increase in the level of indoor PM2.5 was associated with a decrease in Hb (B: ??0.024, SE: 0.011), hematocrit (B: ??0.059, SE: 0.033), and MCV (B: ??0.081, SE: 0.037) and MCH (B: ??0.037, SE: 0.012) in sensor measurements (PM2.5-Lag10).Further, we identified a serum folate-mediated PM effect. The indoor PM exposure wa s significantly associated with decreased Hb, MCV, and MCH in housewives. Taken together, our data show that exposure to indoor PM is a risk factor for anemia in housewives. Blood folate concentration can be a mediating factor in the effect of indoor PM on BIRA. Therefore, folate intake should be recommended to prevent anemia in housewives. Moreover, indoor PM exposure should be managed.
Author(s)
곽영린예신희오종민이동욱양원호김양호하은희
Issued Date
2021
Type
Article
Keyword
indoor particulate matter housewives Hb MCV MCH MCHC folate
DOI
10.3390/ijerph182412890
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7728
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_0b48d0f3274048d8872927c86314da6d&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Direct%20and%20Indirect%20Effects%20of%20Indoor%20Particulate%20Matter%20on%20Blood%20Indicators%20Related%20to%20Anemia&offset=0&pcAvailability=true
Publisher
International Journal of Environmental Research and Public Health
Location
스위스
Language
영어
ISSN
1660-4601
Citation Volume
18
Citation Number
24
Citation Start Page
12890
Citation End Page
12890
Appears in Collections:
Medicine > Medicine
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