Direct and Indirect Effects of Indoor Particulate Matter on Blood Indicators Related to Anemia
- Exposure to indoor particulate matter (PM) is a potential risk factor that increases systemic inflammation and affects erythropoiesis. This study investigated the association between exposure to indoor PM and blood indicators related to anemia (BIRA) in housewives. Indoor PM and blood folate status are important factors in the risk of anemia. This was a housewife cohort study; we recruited 284 housewives in Seoul and Ulsan, Republic of Korea. Indoor exposure to PM2.5 and PM10 was measured by gravimetric analysis and sensors. We investigated the BIRA, such as hemoglobin (Hb), hematocrit, mean corpuscular volume (MCV), mean corpuscular Hb (MCH), and mean corpuscular Hb concentration (MCHC). Statistical analysis was performed by multiple linear regression model and mediation analysis. The association between BIRA and PM was assessed by multiple linear regression models fitted by mediation analyses. The increase in the level of indoor PM2.5 was associated with a decrease in MCV (Beta coefficient (B): ??0.069, Standard error (SE): 0.022) and MCH (B: ??0.019, SE: 0.009) in gravimetric measurements. The increase in the level of indoor PM2.5 was associated with a decrease in Hb (B: ??0.024, SE: 0.011), hematocrit (B: ??0.059, SE: 0.033), and MCV (B: ??0.081, SE: 0.037) and MCH (B: ??0.037, SE: 0.012) in sensor measurements (PM2.5-Lag10).Further, we identified a serum folate-mediated PM effect. The indoor PM exposure wa s significantly associated with decreased Hb, MCV, and MCH in housewives. Taken together, our data show that exposure to indoor PM is a risk factor for anemia in housewives. Blood folate concentration can be a mediating factor in the effect of indoor PM on BIRA. Therefore, folate intake should be recommended to prevent anemia in housewives. Moreover, indoor PM exposure should be managed.
- 곽영린; 예신희; 오종민; 이동욱; 양원호; 김양호; 하은희
- Issued Date
- indoor particulate matter; housewives; Hb; MCV; MCH; MCHC; folate
- International Journal of Environmental Research and Public Health
- Citation Volume
- Citation Number
- Citation Start Page
- Citation End Page
Appears in Collections:
- Medicine > Medicine
- Authorize & License
- Files in This Item:
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.