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Late complications and quality of life assessment for survivors receiving allogeneic hematopoietic stem cell transplantation

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Abstract
Purpose: The survival rates of patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) have improved. However, HSCT can induce significant long-term complications. Therefore, we investigated the late complications and risk factors for quality of life (QOL) post-HSCT. Methods: We retrospectively analyzed 67 adult survivors over 2?years after HSCT between 2015 and 2018 at Ulsan University Hospital, Ulsan, Korea. The survey data including FACT-BMT, Hospital Anxiety and Depression Scale, and NCCN Distress Thermometer were collected as patient-reported outcomes using a tablet PC during a routine practice of survivorship clinic. Results: The median age was 46?years. The most common symptom was fatigue (80.6%). Younger age (< 60?years), acute lymphoblastic leukemia (ALL), chronic graft-versus-host disease (GVHD), and immunosuppressant use were significantly associated with worse QOL and depression. Additionally, younger survivors (< 60?years) showed significantly more fatigue and anxiety compared with elderly survivors (≥ 60?years). Female sex was significantly associated with lower physical well-being and higher distress than male sex. Conclusion: Younger patients (< 60?years), female, ALL, chronic GVHD, and continuous immunosuppressant use were significant risk factors for worse QOL and depression. Hence, creating a more active survivorship care plan after HSCT, specifically for these patients, is required.
Author(s)
김효진이신혜고수진권국주민영주박상혁이유진조재철천재경최윤숙
Issued Date
2021
Type
Article
Keyword
Age groupsAnalysisCancer therapiesMentalFatigueFemaleGender differencesHematopoietic Stem Cell Transplantation - adverse effectsHematopoietic Stem Cell Transplantation - methodsHematopoietic Stem Cell Transplantation - mortalityHematopoietic stem cellsHumansImmunosuppressive agentsImmunotherapyLeukemiaMaleMeasuring instrumentsMedical collegesMedical researchMedicineMedicine &amp; Public HealthExperimentalMiddle AgedNursingNursing ResearchOncologyOriginal ArticlePain MedicineQuality of lifeQuality of Life - psychologyRehabilitation MedicineRepublic of KoreaRetrospective StudiesRisk FactorsSide effectsStem cell transplantationStem cellsSurvival RateSurvivorSurvivors - statistics &amp; numerical dataTablet computersTransplantationTransplantation Conditioning - adverse effectsTransplantation Conditioning - methodsTransplantation Conditioning - mortalityHomologous - adverse effectsHomologous - methodsHomologous - mortalityTransplants &amp; implants
DOI
10.1007/s00520-020-05572-0
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7752
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2415288633&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Late%20complications%20and%20quality%20of%20life%20assessment%20for%20survivors%20receiving%20allogeneic%20hematopoietic%20stem%20cell%20transplantation&amp;offset=0&amp;pcAvailability=true
Publisher
SUPPORTIVE CARE IN CANCER
Location
독일
Language
영어
ISSN
0941-4355
Citation Volume
29
Citation Number
2
Citation Start Page
975
Citation End Page
986
Appears in Collections:
Medicine > Medicine
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