KLI

Dulaglutide as an Effective Replacement for Prandial Insulin in Kidney Transplant Recipients with Type 2 Diabetes Mellitus: A Retrospective Review

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Abstract
Dulaglutide, a weekly injectable glucagon-like peptide-1 receptor agonist, has demonstrated effectiveness when combined with basal insulin. We examined whether the efficacy of dulaglutide is comparable to that of prandial insulin in kidney transplant (KT) recipients with type 2 diabetes mellitus (T2DM) undergoing multiple daily insulin injection (MDI) therapy. Thirty-seven patients, who switched from MDI therapy to basal insulin and dulaglutide, were retrospectively analyzed. Changes in glycosylated hemo-globin (HbA1c) and fasting plasma glucose (FPG) levels, body weight, and basal insulin dose were evaluated over 6 months. Du-laglutide was comparable to three injections of prandial insulin in terms of glycemic control (HbA1c 7.1% vs. 7.0%; 95% confi-dence interval [CI], -0.53 to 0.28; P= 0.53). The basal insulin and dulaglutide combination resulted in a reduction in FPG levels by 9.7 mg/dL (95% CI, 2.09 to 41.54; P= 0.03), in body weight by 4.9 kg (95% CI, 2.87 to 6.98; P< 0.001), and in basal insulin dose by 9.52 IU (95% CI, 5.80 to 3.23; P< 0.001). Once-weekly dulaglutide may be an effective alternative for thrice-daily prandial insu-lin in KT recipients with T2DM currently receiving MDI therapy.
Author(s)
김휘승이지우정창희박중열이우제
Issued Date
2021
Type
Article
Keyword
Diabetes mellitusDulaglutideInsulintype 2
DOI
10.4093/dmj.2020.0180
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7754
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9889417&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Dulaglutide%20as%20an%20Effective%20Replacement%20for%20Prandial%20Insulin%20in%20Kidney%20Transplant%20Recipients%20with%20Type%202%20Diabetes%20Mellitus:%20A%20Retrospective%20Review&amp;offset=0&amp;pcAvailability=true
Publisher
DIABETES METABOLISM JOURNAL
Location
대한민국
Language
영어
ISSN
2233-6079
Citation Volume
45
Citation Number
6
Citation Start Page
948
Citation End Page
953
Appears in Collections:
Medicine > Medicine
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