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Switching from insulin to dulaglutide therapy in patients with type 2 diabetes: A real-world data study

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Abstract
Aim Patients with type 2 diabetes (T2DM) who require injectable therapy have been conventionally treated with insulin. A glucagon-like peptide 1 receptor agonist was recently recommended as first-line injectable treatment, but few studies have investigated the effects of switching from insulin to dulaglutide. This study investigated the clinical efficacy and parameters affecting responses to dulaglutide as an alternative to insulin in patients with T2DM in a real-world clinical setting.

Methods Ninety-eight patients with T2DM who were switched from insulin to dulaglutide therapy were retrospectively evaluated. Changes in HbA1c concentrations were assessed after 6 months of consistent treatment with dulaglutide. Multiple linear regression analysis was performed to evaluate parameters affecting the response to dulaglutide treatment.

Results After treatment with dulaglutide for 6 months, patients experienced changes in HbA1c of -0.95% (95% confidence interval [CI]: -1.30% to -0.59%, P < 0.001) and in body weight of -1.75 kg (95% CI: -2.42 to -1.08 kg, P < 0.001). Multiple linear regression analysis showed that higher baseline HbA1c was significantly associated with a greater reduction in HbA1c. The most frequent adverse events were gastrointestinal symptoms.

Conclusion Switching from insulin to dulaglutide can lead to significant improvement in HbA1c levels and body weight reduction in T2DM patients over 6 months. Higher baseline HbA1c is associated with a better clinical response to dulaglutide.
Author(s)
김휘승이지우정창희박중열이우제
Issued Date
2021
Type
Article
Keyword
AnalysisBody weightCare and treatmentComplications and side effectsdiabetes mellitusDiabetes therapydulaglutideGLP‐1 receptor agonistGlycosylated hemoglobinInsulinPeptidesType 2 diabetes
DOI
10.1002/dmrr.3466
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7755
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2524361764&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Switching%20from%20insulin%20to%20dulaglutide%20therapy%20in%20patients%20with%20type%202%20diabetes:%20A%20real-world%20data%20study&amp;offset=0&amp;pcAvailability=true
Publisher
DIABETES-METABOLISM RESEARCH AND REVIEWS
Location
미국
Language
영어
ISSN
1520-7552
Citation Volume
37
Citation Number
8
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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