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Prevalence and risk factors of bowel symptoms in Korean patients with ulcerative colitis in endoscopic remission: a retrospective study

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Abstract
Background: Many patients with ulcerative colitis (UC) in clinical remission frequently complain of bowel symptoms such as increased stool frequency (SF) and rectal bleeding (RB). However, studies on these patient-reported outcomes in patients with inactive UC are limited, especially in Korea. Therefore, we investigated the prevalence and risk factors of bowel symptoms in Korean patients with inactive UC.

Methods: We investigated the prevalence of bowel symptoms in patients with endoscopically quiescent UC between June 1989 and December 2016 using a well-characterized referral center-based cohort. The Mayo clinic score (MCS) was used to evaluate bowel symptoms at the most recent visit near the date of endoscopy. Clinical characteristics of the patients were compared based on the presence or absence of bowel symptoms.

Results: Overall, 741 patients with endoscopically quiescent UC were identified, of whom 222 (30%) and 48 (6.5%) had an SF and RB subscore of >= 1, respectively. Patients with bowel symptoms (SF + RB >= 1; n = 244 [32.9%]) had higher rates of left-sided colitis (E2) or extensive colitis (E3) than patients without bowel symptoms (SF + RB = 0; n = 497 [67.1%]; P = 0.002). Multivariate analysis revealed that female sex (odds ratio [OR]: 1.568; 95% confidence interval [CI]: 1.023-2.402; P = 0.039) and E2 or E3 (OR 1.411; 95% CI 1.020-1.951; P = 0.038) were the significant risk factors for increased SF.

Conclusions: This study revealed that one-third of patients with endoscopically quiescent UC reported increased SF. Female sex and disease extent may be associated with bowel symptoms.
Author(s)
김정석김진용남광우노수민명승재박상형박재철변정식양동훈양석균예병덕오은혜오준호이호수함남석황성욱
Issued Date
2021
Type
Article
Keyword
Patient-reported outcomeBowel symptomsRectal bleedingStool frequencyUlcerative colitis
DOI
10.1186/s12876-020-01597-1
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7759
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_038afc6ee36f4eb0a8d804132a1bd77b&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Prevalence%20and%20risk%20factors%20of%20bowel%20symptoms%20in%20Korean%20patients%20with%20ulcerative%20colitis%20in%20endoscopic%20remission:%20a%20retrospective%20study&offset=0&pcAvailability=true
Publisher
BMC GASTROENTEROLOGY
Location
영국
Language
영어
ISSN
1471-230X
Citation Volume
21
Citation Number
1
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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