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Immune Checkpoint Programmed Cell Death Protein-1 (PD-1) Expression on Bone Marrow T Cell Subsets in Patients With Plasma Cell Myeloma

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Abstract
Background: Plasma cell myeloma (PCM) is caused by immune dysregulation. We evaluated the expression of immune checkpoint programmed cell death protein-1 (PD-1) on T cell subsets in PCM patients according to disease course and cytogenetic abnormalities. This study aimed to find a target group suitable for therapeutic use of PD-1 blockade in PCM.

Methods: A total of 188 bone marrow (BM) samples from 166 PCM patients and 32 controls were prospectively collected between May 2016 and May 2017. PD-1 expression on BM T cell subsets was measured using flow cytometry.

Results: At diagnosis, the median PD-1 expression on CD4(+) T cells was 24.6%, which did not significantly differ from that in controls. After stem cell transplantation, PD-1 expression on CD+' T cells was higher than that at diagnosis (P<0.001), regardless of residual disease. PD-1 expression on CD4(+) T cells in patients with residual disease after chemotherapy was significantly higher than that at diagnosis (P=0.001) and after complete remission following chemotherapy (P=0.044). PD-1 expression on CD8(+) T cells was higher in PCM patients with cytogenetic abnormalities, including monosomy 13, 1q gain, complex karyotype, and hypodiploidy.

Conclusions: PD-1 blockade might have therapeutic potential in refractory PCM patients after chemotherapy, especially in those with high- or intermediate-risk cytogenetic abnormalities.
Author(s)
박찬정서을주서철원윤덕현이정희장성수조영욱Eunkyoung YouMin Young Lee
Issued Date
2021
Type
Article
Keyword
Plasma cell myelomaImmune checkpoint programmed cell death protein-1 (PD-1)Flow cytometryT cell subset
DOI
10.3343/alm.2021.41.3.259
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7760
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9791049&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Immune%20Checkpoint%20Programmed%20Cell%20Death%20Protein-1%20(PD-1)%20Expression%20on%20Bone%20Marrow%20T%20Cell%20Subsets%20in%20Patients%20With%20Plasma%20Cell%20Myeloma&amp;offset=0&amp;pcAvailability=true
Publisher
ANNALS OF LABORATORY MEDICINE
Location
대한민국
Language
영어
ISSN
2234-3806
Citation Volume
41
Citation Number
3
Citation Start Page
259
Citation End Page
267
Appears in Collections:
Medicine > Medicine
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