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Amsterdam International Consensus Meeting: tumor response scoring in the pathology assessment of resected pancreatic cancer after neoadjuvant therapy

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Abstract
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Abstract


Histopathologically scoring the response of pancreatic ductal adenocarcinoma (PDAC) to neoadjuvant treatment can guide the selection of adjuvant therapy and improve prognostic stratification. However, several tumor response scoring (TRS) systems exist, and consensus is lacking as to which system represents best practice. An international consensus meeting on TRS took place in November 2019 in Amsterdam, The Netherlands. Here, we provide an overview of the outcomes and consensus statements that originated from this meeting. Consensus (≥80% agreement) was reached on a total of seven statements: (1) TRS is important because it provides information about the effect of neoadjuvant treatment that is not provided by other histopathology-based descriptors. (2) TRS for resected PDAC following neoadjuvant therapy should assess residual (viable) tumor burden instead of tumor regression. (3) The CAP scoring system is considered the most adequate scoring system to date because it is based on the presence and amount of residual cancer cells instead of tumor regression. (4) The defining criteria of the categories in the CAP scoring system should be improved by replacing subjective terms including "minimal" or "extensive" with objective criteria to evaluate the extent of viable tumor. (5) The improved, consensus-based system should be validated retrospectively and prospectively. (6) Prospective studies should determine the extent of tissue sampling that is required to ensure adequate assessment of the residual cancer burden, taking into account the heterogeneity of tumor response. (7) In future scientific publications, the extent of tissue sampling should be described in detail in the "Materials and methods" section.
Author(s)
홍승모Aatur SinghiAlyssa KrasinskasAnthony J GillArantza Farina SarasquetaBas Groot KoerkampBoris V JanssenCaroline S VerbekeChanjuan ShiClaudio DoglioniClaudio LuchiniEline C SoerFaik TutucuFiona CampbellHuamin WangIrene EspositoJeffrey KaplanJoanne VerheijJohan OfferhausJohanna
Issued Date
2021
Type
Article
Keyword
Pancreatic cancer
DOI
10.1038/s41379-020-00683-9
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7764
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2449993750&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Amsterdam%20International%20Consensus%20Meeting:%20tumor%20response%20scoring%20in%20the%20pathology%20assessment%20of%20resected%20pancreatic%20cancer%20after%20neoadjuvant%20therapy&offset=0&pcAvailability=true
Publisher
MODERN PATHOLOGY
Location
미국
Language
영어
ISSN
0893-3952
Citation Volume
34
Citation Number
1
Citation Start Page
4
Citation End Page
12
Appears in Collections:
Medicine > Medicine
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