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Kinetics of Serological Response in Patients with Severe Fever with Thrombocytopenia Syndrome

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Abstract
Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV). We investigated the detailed kinetics of serologic response in patients with SFTS. Twenty-eight patients aged >= 18 years were enrolled between July 2015 and October 2018. SFTS was confirmed by detecting SFTSV RNA in their plasma using reverse transcription polymerase chain reaction. SFTSV-specific IgG and IgM were measured using immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA). We found that SFTSV-specific IgG was detected at days 5-9 after symptom onset, and its titer was rising during the course of disease. SFTSV-specific IgM titer peaked at around week 2-3 from symptom onset. The SFTSV-specific seropositive rates for days 5-9, 10-14, 15-19, and 20-24 from symptom onset using IFA and ELISA were 63%, 76%, 90%, and 100%, and 58%, 86%, 100%, and 100%, respectively, for IgG, whereas they were 32%, 62%, 80%, and 100%, and 53%, 62%, 70%, and 100%, respectively, for IgM. The delayed IgM response could be attributed to the low sensitivity of SFTSV-specific IgM IFA or ELISA and/or impaired immune responses. The IgM test using IFA or ELISA that we used in this study is, therefore, insufficient for the early diagnosis of SFTS.
Author(s)
기선호김민재김민철김성한김양수라상현박성연박세윤이근화이상오정용필최상호
Issued Date
2021
Type
Article
Keyword
severe fever with thrombocytopenia syndrome (SFTS)viral loadimmunoglobulin G (IgG)immunoglobulin M (IgM)immunofluorescence assay (IFA)enzyme-linked immunosorbent assay (ELISA)
DOI
10.3390/v13010006
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7768
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_e3cf531768f34ae8a2330bb07639129d&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Kinetics%20of%20Serological%20Response%20in%20Patients%20with%20Severe%20Fever%20with%20Thrombocytopenia%20Syndrome&offset=0&pcAvailability=true
Publisher
VIRUSES-BASEL
Location
스위스
Language
한국어
ISSN
1999-4915
Citation Volume
13
Citation Number
1
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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