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Reappraisal of the prognostic value of Epstein-Barr virus status in monomorphic post-transplantation lymphoproliferative disorders-diffuse large B-cell lymphoma

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Abstract
The role of the Epstein-Barr virus (EBV) status in the blood for predicting survival in post-transplantation lymphoproliferative disorders-diffuse large B-cell lymphoma (PTLD-DLBCL) is unknown. We evaluated the prognostic values of pre-treatment EBV-encoded small RNA (EBER) detected with in situ hybridization in tissues and EBV DNA in the whole blood (WB) and plasma in 58 patients with monomorphic PTLD-DLBCL after solid organ transplantation. There were no significant differences in the rates of overall response, complete response, and survival according to EBER EBV and WB EBV status. In contrast, patients with positive plasma EBV DNA had significantly lower rates of overall response (60.0% vs. 94.4%, P=0.043) and complete response (40.0% vs. 88.9%, P=0.019) as well as worse progression-free survival (PFS) (P=0.035) and overall survival (OS) (P=0.039) compared with patients with negative plasma EBV DNA. In multivariate analysis, plasma EBV DNA positivity was a significantly unfavorable prognostic factor for PFS [hazard ratio (HR) 4.92, 95% confidence interval (CI) 1.22-19.86, P=0.025] and OS (HR 4.48, 95% CI 1.14-17.63, P=0.032). Despite small number of 6 patients with plasma EBV positivity, plasma EBV DNA positivity might be more prognostic for survival than EBER or WB EBV DNA positivity in patients with monomorphic PTLD-DLBCL.
Author(s)
김경원김좌훈류진숙박찬식서철원성흥섭윤덕현이상욱이윤세정아라조형우채은진허주영
Issued Date
2021
Type
Article
Keyword
CancerOncology
DOI
10.1038/s41598-021-82534-4
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7772
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_b201bc79c1c742fa8614169e3b87ed04&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Reappraisal%20of%20the%20prognostic%20value%20of%20Epstein-Barr%20virus%20status%20in%20monomorphic%20post-transplantation%20lymphoproliferative%20disorders-diffuse%20large%20B-cell%20lymphoma&offset=0&pcAvailability=true
Publisher
SCIENTIFIC REPORTS
Location
영국
Language
영어
ISSN
2045-2322
Citation Volume
11
Citation Number
1
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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