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Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain

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Abstract
In patients with advanced-stage cancer, cancer-associated anorexia affects treatment success and patient survival. However, the underlying mechanism is poorly understood. Here, we show that Dilp8, a Drosophila homologue of mammalian insulin-like 3 peptide (INSL3), is secreted from tumour tissues and induces anorexia through the Lgr3 receptor in the brain. Activated Dilp8-Lgr3 signalling upregulated anorexigenic nucleobinding 1 (NUCB1) and downregulated orexigenic short neuropeptide F (sNPF) and NPF expression in the brain. In the cancer condition, the protein expression of Lgr3 and NUCB1 was significantly upregulated in neurons expressing sNPF and NPF. INSL3 levels were increased in tumour-implanted mice and INSL3-treated mouse hypothalamic cells showed Nucb2 upregulation and Npy downregulation. Food consumption was significantly reduced in intracerebrospinal INSL3-injected mice. In patients with pancreatic cancer, higher serum INSL3 levels increased anorexia. These results indicate that tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding hormones through the Lgr3/Lgr8 receptor in Drosophila and mammals.

Yeom et al. demonstrate that tumour cell-secreted Dilp8/INSL3 activates Lgr3 signalling and modulates expression of distinct feeding hormones such as NUCB1 and sNPF, thereby inducing anorexia in cancer.
Author(s)
염은별신헤미유원백전은성김석호홍성현권대우유태훈서재명김송철이규선유권
Issued Date
2021
Type
Article
Keyword
Cancer metabolismHormonesMetabolic diseases
DOI
10.1038/s41556-020-00628-z
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7773
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_gale_infotracacademiconefile_A655717821&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Tumour-derived%20Dilp8%2FINSL3%20induces%20cancer%20anorexia%20by%20regulating%20feeding%20neuropeptides%20via%20Lgr3%2F8%20in%20the%20brain&offset=0&pcAvailability=true
Publisher
NATURE CELL BIOLOGY
Location
미국
Language
영어
ISSN
1465-7392
Citation Volume
23
Citation Number
2
Citation Start Page
172
Citation End Page
172
Appears in Collections:
Medicine > Medicine
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