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Circulating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma

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Abstract
Early recurrence in pancreatic ductal adenocarcinoma (PDAC) is a decisive factor in determining a patient's prognosis. We determined in our current study whether circulating tumour cells (CTCs) exist in the blood of PDAC patients and can be used as a predictor of recurrence patterns (i.e. time and site) after surgical resection. Between December 2017 and November 2018, the mononuclear cell layer was obtained from the peripheral blood of 36 patients diagnosed with PDAC. CTCs were then isolated using the CD-PRIME (TM) platform and detected via immunostaining. The patient records were analyzed to correlate these data with survival and recurrence patterns. Twelve patients were CTC-positive (33.3%) and showed a significantly frequent rate of systemic recurrence (distant metastases and peritoneal dissemination) (p=0.025). On multi-variable logistic regression analysis, CTC positivity was an independent risk factor for early recurrence (p=0.027) and for systemic recurrence (p=0.033). In summary, the presence or absence of CTC in the blood of the patients with PDAC could help predict the recurrence pattern after surgery. PDAC patients with CTC positivity at tumour diagnosis should therefore undergo a comprehensive strategy for systemic therapy and active monitoring to detect possible early recurrence.
Author(s)
박예종전혜령최휘완황대욱이재훈송기병이우형권재우하수연전은성김송철
Issued Date
2021
Type
Article
Keyword
Gastrointestinal cancerMedical researchSurgical oncologyTumour biomarkers
DOI
10.1038/s41598-020-80383-1
URI
http://oak.ulsan.ac.kr/handle/2021.oak/7774
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_4b331bd32c6c421d861ccfd8231336f2&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Circulating%20tumour%20cells%20as%20an%20indicator%20of%20early%20and%20systemic%20recurrence%20after%20surgical%20resection%20in%20pancreatic%20ductal%20adenocarcinoma&offset=0&pcAvailability=true
Publisher
SCIENTIFIC REPORTS
Location
미국
Language
영어
ISSN
2045-2322
Citation Volume
11
Citation Number
1
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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