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Comparison Between Familial and Sporadic Non-medullary Thyroid Carcinoma: A Retrospective Individual Risk Factor-Matched Cohort Study

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Abstract
Background: This study aimed to compare clinicopathologic features and outcomes between patients with familial non-medullary thyroid carcinoma (FNMTC) and patients with sporadic non-medullary thyroid carcinoma (SNMTC) after performing individual risk factor-matching. Additionally, the study evaluated a dynamic risk stratification (DRS) system to validate its usefulness for familial-type thyroid carcinoma. Methods: After individual risk factor-matching, 286 patients remained in the FNMTC group, and 858 patients were assigned to the SNMTC group consisting of papillary thyroid carcinoma (PTC). The prognostic outcomes were compared between the two groups in a matched cohort. Results: During the mean follow-up period of 142?months, recurrences were experienced by 64 patients in the sporadic group (7.5%) and 29 patients in the familial group (10.1%). In the multivariate analysis, the independent risk factors for recurrence were primary tumor size (p = 0.033), gross extrathyroidal extension (p = 0.001), and lymph node metastasis (p < 0.001). The independent risk factors did not include family history alone (p = 1.101) or the number of affected family members (p = 0.122 for 2 members and p = 0.625 for ≥ 3 members). In this matched-cohort study, the DRS system was well adjusted in the FNMTC and SNMTC groups. Moreover, the proportion of DRS categories and the recurrence rate in each DRS category were similar between the familial and sporadic groups. Conclusions: Family history did not present a statistically significant association with a poor prognosis for PTC patients. With a family history of PTC alone, less aggressive treatment could be considered. In this matched cohort, DRS was adjusted well and could be useful in predicting prognosis, even for PTC patients with a family history of PTC.
Author(s)
이유미전민지김원웅정기욱백정환송영기성태연홍석준
Issued Date
2021
Type
Article
Keyword
CancerCarcinomaEndocrine TumorsGenetic aspectsHumansMedical researchMedicineMedicine &amp; Public HealthExperimentalLocal - geneticsOncologyRetrospective StudiesRisk FactorsSurgerySurgical OncologyThyroid diseasesThyroid Neoplasms - geneticsThyroid Neoplasms - surgeryThyroidectomy
DOI
10.1245/s10434-020-09025-0
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7780
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2434755148&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Comparison%20Between%20Familial%20and%20Sporadic%20Non-medullary%20Thyroid%20Carcinoma:%20A%20Retrospective%20Individual%20Risk%20Factor-Matched%20Cohort%20Study&amp;offset=0&amp;pcAvailability=true
Publisher
ANNALS OF SURGICAL ONCOLOGY
Location
미국
Language
영어
ISSN
1068-9265
Citation Volume
28
Citation Number
03
Citation Start Page
1722
Citation End Page
1730
Appears in Collections:
Medicine > Medicine
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