KLI

Serum procalcitonin as a biomarker for differentiating between infectious and non-infectious fever after pancreas transplantation

Metadata Downloads
Abstract
Laboratory biomarkers that can differentiate non-infectious fever from infectious fever after pancreas transplantation have yet to be discovered. Non-infectious fever was defined as the presence of fever (>38.3 degrees C) in the absence of a documented clinical diagnosis of infection or a positive culture. Among 184 consecutive recipients, a total of 91 recipients developed fever within 1-month post-transplant, of whom 46 had infectious fever and 45 had non-infectious fever at our center between August 2014 and July 2019. The onset of fever was earlier in the non-infectious fever group (14.4 +/- 3.7 post-transplant days) compared with the infectious fever group (16.5 +/- 5.8 post-transplant days; p = .033). Multivariate analysis showed that serum procalcitonin at the peak of fever could significantly differentiate infectious fever from non-infectious fever (OR 53.378, 95% CI: 6.819-417.802, p < .001). The area under the curve for differentiating between the two groups was 0.853 (95% CI, 0.780-0.926) for procalcitonin and 0.667 (95% CI, 0.549-0.785) for CRP. The best cutoff values of serum procalcitonin and CRP were 0.405 ng/ml (sensitivity, 77.1%; specificity, 80.8%) and 7.355 mg/dl (sensitivity, 66.7%; specificity, 67.3%), respectively. Serum procalcitonin may be useful for differentiating non-infectious fever from infectious fever after pancreas transplantation.
Author(s)
고영민권현욱김동현김성한김영훈신성심예은이상오임성준정주희한덕종
Issued Date
2021
Type
Article
Keyword
AnalysisAntithymocyte globulinnon‐infectious feverPancreaspancreas transplantationprocalcitonin Transplantation
DOI
10.1111/ctr.14224
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7781
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2477517669&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Serum%20procalcitonin%20as%20a%20biomarker%20for%20differentiating%20between%20infectious%20and%20non-infectious%20fever%20after%20pancreas%20transplantation&amp;offset=0&amp;pcAvailability=true
Publisher
CLINICAL TRANSPLANTATION
Location
미국
Language
한국어
ISSN
0902-0063
Citation Volume
35
Citation Number
4
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.