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Large tumor size, lymphovascular invasion, and synchronous metastasis are associated with the recurrence of solid pseudopapillary neoplasms of the pancreas

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Abstract
Background: Solid pseudopapillary neoplasms (SPNs) of the pancreas have low malignant potential. However, malignant SPNs are not fully understood.

Methods: To evaluate risk factors affecting malignant potential, the clinicopathologic features of 375 surgically resected SPNs were compared.

Results: Fifty (13.3%) had malignant histologic features. Twenty-seven and 22 had perineural and lymphovascular invasions, respectively. Adjacent organ invasion was noted in 9 cases. Recurrence occurred in 8 cases. The median recurrence time after surgical resection was 67 months and was associated with a higher pT category (P = 0.001), lymphovascular invasion (P < 0.001), and synchronous metastasis (P < 0.001). SPN patients with malignant histologic features had worse recurrence-free survival (RFS; 10-year survival rate, 73.2%) than those without malignant histologic features (96.3%; P = 0.01). Patients with a higher pT category (P = 0.04), synchronous metastasis (P < 0.01), and lymphovascular invasion (P < 0.01) had worse RFS. Lymphovascular invasion (P = 0.042) and a higher T category (P = 0.002) were poor prognostic factors for recurrence.

Conclusion: Lymphovascular invasion and a higher T category were worse prognostic factors for recurrence in SPN patients with malignant histologic features. For SPN patients with malignant histologic features, a longer follow-up may be required.
Author(s)
김성주김송철김지훈성유나송기병이고은이상수이재훈홍승모황대욱
Issued Date
2021
Type
Article
Keyword
Papillary* / surgeryHumansLocalPancreasPancreatectomy / adverse effectsPancreatic Neoplasms* / surgeryPrognosisRetrospective Studies
DOI
10.1016/j.hpb.2020.05.015
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7784
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2423516708&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Large%20tumor%20size,%20lymphovascular%20invasion,%20and%20synchronous%20metastasis%20are%20associated%20with%20the%20recurrence%20of%20solid%20pseudopapillary%20neoplasms%20of%20the%20pancreas&amp;offset=0&amp;pcAvailability=true
Publisher
HPB
Location
영국
Language
영어
ISSN
1365-182X
Citation Volume
23
Citation Number
2
Citation Start Page
220
Citation End Page
230
Appears in Collections:
Medicine > Medicine
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