Newly Developed N-butyl Cyanoacrylate (EG glue) for Arterial Embolization: A Preclinical Study in Rabbit Renal Artery

Abstract

N-Butyl cyanoacrylate (NBCA) glue has been widely utilized for the endovascular management of various vascular pathologies ranging from acute visceral hemorrhage to arteriovenous malformations. Here, we investigate the effectiveness and safety of the newly developed NBCA glue (i.e., EG glue) compared to conventional glue (Histoacryl) for transcatheter arterial embolization (TAE) in rabbit renal arteries. Compared to Histoacryl, EG glue had similar physical properties and embolic efficacy. In both groups, necrotizing lesions in the vessel walls were observed in all rabbits, without significant differences. Based on these results, we believe that EG glue could be a promising alternate embolic material for treating various diseases.