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Long?term survival outcomes of repeat lumpectomy for ipsilateral breast tumor recurrence: a propensity score?matched analysis

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Alternative Title
Long?term survival outcomes of repeat lumpectomy for ipsilateral breast tumor recurrence: a propensity score?matched analysis
Abstract
Purpose This study aimed to compare long-term survival outcomes of repeat lumpectomy with total mastectomy after
ipsilateral breast tumor recurrence (IBTR) using propensity score matching (PSM).
Methods We retrospectively analyzed patients with IBTR who had undergone initial breast-conserving surgery for breast
cancer at our institution between January 1990 and December 2013. The Kaplan?Meier method and Cox proportional hazards
model were used to compare survival rates between the two groups. PSM was performed using the following covariates:
age at initial operation, initial T stage, N stage, hormone receptor status, human epidermal growth factor receptor 2 status,
chemotherapy, radiotherapy, and IBTR tumor size.
Results We enrolled 335 IBTR patients with a median follow-up of 126.6 months. No significant differences were observed
in the 5-year overall survival (OS), breast cancer-specific survival (BCSS), OS after IBTR, and BCSS after IBTR and
10-year survival probability between the two groups in a multivariate analysis. After PSM, patients who had undergone
repeat lumpectomy and total mastectomy (n = 90 in both groups) were included. No significant differences were observed
in the 10-year OS (hazard ratio [HR] 1.08, 95% confidence interval [CI] 0.49?2.39), BCSS (HR 0.83, 95% CI 0.35?1.95),
OS after IBTR (HR 0.83, 95% CI 0.38?1.83), and BCSS after IBTR (HR 0.64, 95% CI 0.28?1.47) between the two groups.
Conclusions No significant differences were observed in survival outcomes between patients with IBTR who underwent
repeat lumpectomy or total mastectomy. Our results can be helpful in selecting the appropriate surgical method for IBTR.
Author(s)
이새별안세현손병호이종원김희정고범석정일용김지선백수연
Issued Date
2021
Type
Article
Keyword
Breast cancerBreast-conserving surgeryIpsilateral breast tumor recurrenceRepeat lumpectomy
DOI
10.1007/s10549-020-05932-8
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7808
Publisher
BREAST CANCER RESEARCH AND TREATMENT
Location
미국
Language
영어
ISSN
0167-6806
Citation Volume
185
Citation Number
1
Citation Start Page
155
Citation End Page
164
Appears in Collections:
Medicine > Medicine
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