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PDK2 Deficiency Prevents Ovariectomy-Induced Bone Loss in Mice by Regulating the RANKL-NFATc1 Pathway During Osteoclastogenesis

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Abstract
Estrogen deficiency leads to osteoporosis as a result of an imbalance in bone remodeling due to greater bone resorption. Estrogen deficiency increases the osteoclastic resorption of bone, and many of the FDA-approved therapies for osteoporosis are antiresorptive drugs that mainly act by reducing osteoclast activity. The mitochondrial enzyme pyruvate dehydrogenase kinase (PDK) is a critical regulator of aerobic glycolysis that exerts its effects by phosphorylating the pyruvate dehydrogenase complex (PDC), which is responsible for oxidative phosphorylation. In the present study, we found that during osteoclast differentiation, PDK2 expression increased more than that of the other PDK isoenzymes. Bone loss was delayed and the number of osteoclasts was lower in ovariectomized (OVX) Pdk2
Author(s)
고정민Byung-Gyu KimHye Jin HamIn-Kyu LeeJae-Han JeonJe-Yong ChoiJi-Min LeeMin-Ji KimSeung Mi LeeSun Joo Lee
Issued Date
2021
Type
Article
Keyword
AnalysisCELL SIGNALINGCellular signal transductionDrug approvalEstrogenGene expressionGENETIC ANIMAL MODELGenetic researchIsoenzymesOSTEOCLASTOSTEOPOROSISProtein bindingTRANSCRIPTION FACTOR
DOI
10.1002/jbmr.4202
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7811
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2456410725&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,PDK2%20Deficiency%20Prevents%20Ovariectomy-Induced%20Bone%20Loss%20in%20Mice%20by%20Regulating%20the%20RANKL-NFATc1%20Pathway%20During%20Osteoclastogenesis&offset=0&pcAvailability=true
Publisher
JOURNAL OF BONE AND MINERAL RESEARCH
Location
미국
Language
영어
ISSN
0884-0431
Citation Volume
36
Citation Number
3
Citation Start Page
553
Citation End Page
566
Appears in Collections:
Medicine > Medicine
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