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Prognostic value of p53 expression in hormone receptor-positive and human epidermal growth factor receptor 2-negative breast cancer patients receiving neoadjuvant chemotherapy

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Abstract
Purpose The aim of this study was to determine whether the outcome to neoadjuvant chemotherapy (NAC) can be predicted by analyzing p53 expression in hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer patients. Methods We retrospectively reviewed 594 patients diagnosed with stage I-III HR-positive, HER2-negative breast cancer, and treated with NAC at the Asan Medical Center between 2008 and 2014. Expression of p53 was assessed, and overall survival (OS) and breast cancer-specific survival (BCSS) were investigated and compared between groups. Results At a median follow-up period of 69.8 months, OS and BCSS were higher in the p53-negative (p53(-)) group than in the p53-positive (p53(+)) group. Five-year OS was 95.4% in the p53(-) and 92.1% in the p53(+) group (p = 0.005). BCSS was 96.2% in the p53(-) group and 93% in the p53(+) group (p = 0.008). Conclusion High expression of immunohistochemically detected p53 was strongly and significantly associated with decreased OS and BCSS than low p53 expression, suggesting that p53 may be a powerful prognostic factor in HR-positive, HER2-negative breast cancer patients receiving NAC.
Author(s)
이새별안세현손병호이종원김희정고범석정일용김지선Loai Saleh Alvinssad
Issued Date
2021
Type
Article
Keyword
Adjuvant treatmentBreast cancerCancerCancer patientsClinical TrialComparative analysisEpidermal growth factorHealth aspectsMedical centersMedical collegesMedicineMedicine & Public HealthOncologyPrognosisTumor proteins
DOI
10.1007/s10549-021-06134-6
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7832
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2491061667&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Prognostic%20value%20of%20p53%20expression%20in%20hormone%20receptor-positive%20and%20human%20epidermal%20growth%20factor%20receptor%202-negative%20breast%20cancer%20patients%20receiving%20neoadjuvant%20chemotherapy&offset=0&pcAvailability=true
Publisher
BREAST CANCER RESEARCH AND TREATMENT
Location
스위스
Language
영어
ISSN
0167-6806
Citation Volume
187
Citation Number
2
Citation Start Page
447
Citation End Page
454
Appears in Collections:
Medicine > Medicine
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