KLI

Evaluation of Sepsis-Induced Coagulopathy in Critically Ill Pediatric Patients with Septic Shock

Metadata Downloads
Abstract
Background ?Coagulopathy is a common serious complication of sepsis and septic shock; thus, its early detection and prompt management are important. For this purpose, recently the sepsis-induced coagulopathy (SIC) score was proposed. Methods ?We modified the SIC score for critically ill children with septic shock and evaluated its performance in comparison to several coagulopathy diagnostic scoring systems. Results ?Among 135 included patients, a significant number of patients were diagnosed with coagulopathy using different coagulopathy diagnostic criteria (up to 84.4% using the SIC score). The modified SIC score, comprising the pediatric sequential organ failure assessment (pSOFA) score, prothrombin time, and D-dimer, was used to diagnose SIC in 68 (50.4%) patients. It was well correlated with the pSOFA score and the International Society on Thrombosis and Haemostasis disseminated intravascular coagulation (DIC) score, as well as the SIC score (p < 0.001). The overall 28-day mortality rate was 18.7%. Patients with coagulopathy had worse clinical outcomes compared to those without coagulopathy. The modified SIC score was identified as an independent prognostic factor for 28-day mortality. The area under the receiver operating characteristic curve for performance of the modified SIC score to predict 28-day mortality evaluated was 0.771 (95% confidence interval: 0.658-0.883), better than those of the SIC and ISTH DIC scores (p < 0.05). Conclusion ?Critically ill pediatric patients with septic shock frequently had concomitant coagulopathy. The modified SIC score showed good ability to predict 28-day mortality, suggesting its potential as a prognostic factor in these critically ill pediatric patients.
Author(s)
박성종장원경
Issued Date
2021
Type
Article
Keyword
AdolescentAge FactorsBlood Coagulation*ChildPreschoolCritical IllnessDecision Support Techniques*Disseminated Intravascular Coagulation / bloodDisseminated Intravascular Coagulation / diagnosis*Disseminated Intravascular Coagulation / etiologyDisseminated Intravascular Coagulation / mortalityFemaleHumansPediatricMalePredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsSeptic / bloodSeptic / complications*Septic / diagnosisSeptic / mortalityTime Factors
DOI
10.1055/s-0040-1718736
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7835
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_crossref_primary_10_1055_s_0040_1718736&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Evaluation%20of%20Sepsis-Induced%20Coagulopathy%20in%20Critically%20Ill%20Pediatric%20Patients%20with%20Septic%20Shock&amp;offset=0&amp;pcAvailability=true
Publisher
THROMBOSIS AND HAEMOSTASIS
Location
독일
Language
영어
ISSN
0340-6245
Citation Volume
121
Citation Number
4
Citation Start Page
457
Citation End Page
463
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.