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Spatial Distribution and Prognostic Implications of Tumor-Infiltrating FoxP3(-) CD4(+) T Cells in Biliary Tract Cancer

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Abstract
Purpose The clinical implications of tumor-infittratingT cell subsets and their spatial distribution in biliary tract cancer (BTC) patients treated with gemcitabine plus cisplatin were investigated.

Materials and Methods A total of 52 BTC patients treated with palliative gemcitabine plus cisplatin were included. Multiplexed immunohistochemistry was performed on tumor tissues, and immune infiltrates were separately analyzed for the stroma, tumor margin, and tumor core.

Results The density of CD8(+) T cells, FoxP3(-) CD4(+) helper T cells, and FoxP3(+) CD4(-) regulatory T cells was significantly higher in the tumor margin than in the stroma and tumor core. The density of LAG3(-) or TIM3-expressing CD8(+) T cell and FoxP3(-) CD4(+) helper T cell infiltrates was also higher in the tumor margin. In extrahepatic cholangiocarcinoma, there was a higher density of T cell subsets in the tumor core and regulatory T cells in all regions. A high density of FoxP3(-) CD4(+) helper T cells in the tumor margin showed a trend toward better progression-free survival (PFS) (p=0.092) and significantly better overall survival (OS) (p=0.012). In multivariate analyses, a high density of FoxP3(-) CD4(+) helper T cells in the tumor margin was independently associated with favorable PFS and OS.

Conclusion The tumor margin is the major site for the active infiltration of T cell subsets with higher levels of LAG3 and TIM3 expression in BTC. The density of tumor margin-infiltrating FoxP3(-) CD4(+) helper T cells may be associated with clinical outcomes in BTC patients treated with gemcitabine plus cisplatin.
Author(s)
김규표김기훈김단비김상엽김좌훈김형돈류백렬류연미송기병송기원신재훈유창훈이선민이재훈정동환정재호홍승모황대욱
Issued Date
2021
Type
Article
Keyword
Biliary tract neopla는CD4+ helper T cellsMultiplexed immunohistochemistryOriginalTumor margin의학일반
DOI
10.4143/crt.2020.704
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7840
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9672968&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Spatial%20Distribution%20and%20Prognostic%20Implications%20of%20Tumor-Infiltrating%20FoxP3(-)%20CD4(%2B)%20T%20Cells%20in%20Biliary%20Tract%20Cancer&offset=0&pcAvailability=true
Publisher
CANCER RESEARCH AND TREATMENT
Location
대한민국
Language
영어
ISSN
1598-2998
Citation Volume
53
Citation Number
1
Citation Start Page
162
Citation End Page
171
Appears in Collections:
Medicine > Medicine
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