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Factors associated with alexithymia in adults with epilepsy

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Abstract
Purpose: The relationship between epilepsy and alexithymia, characterized by the inability to feel or express emotion, remains incompletely understood. We investigated alexithymia and its association with epilepsy-related factors in patients with epilepsy (PWE).

Methods: In this cross-sectional study, PWE and healthy control subjects were recruited. Alexithymia was assessed using the Toronto Alexithymia Scale-20 (TAS-20). The Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder-7 (GAD-7) were also administered to assess depression and anxiety, respectively. Mediation analysis was conducted using a two-stage regression method.

Results: Ninety adult PWE and 161 healthy control subjects were included in the study. PWE had significantly higher TAS-20 scores (B = 2.445, p = 0.014) than controls, but the prevalence of alexithymia, defined as TAS-20 >= 61, did not differ between PWE and control subjects after controlling for confounders (15.6% vs. 6.2%, respectively; p = 0.873). Uncontrolled seizures significantly increased alexithymia through depression (B = 3.536, p = 0.006), and this effect was responsible for 61.2% of the total effect on alexithymia. The direct effects of uncontrolled seizures on alexithymia were not significant. In contrast, AED polytherapy had significant direct effects on alexithymia (B = 4.489, p = 0.037) independent of depression. The indirect effects of AED polytherapy via depression did not reach statistical significance (B = 2.371, p = 0.066).

Conclusions: Alexithymia was more severe, but not more prevalent, in PWE than in healthy controls. AED polytherapy was directly associated with alexithymia, while uncontrolled seizures were indirectly related to alexithymia through depressive symptoms. (C) 2020 Elsevier Inc. All rights reserved.
Author(s)
이상암Eun Ju ChoiHye-Ran ChoiHyo Jae KimSoo Jeong Kim
Issued Date
2021
Type
Article
Keyword
AlexithymiaAntiepileptic drugAnxietyDepressionEpilepsyUncontrolled seizures
DOI
10.1016/j.yebeh.2020.107582
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7849
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2466770344&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Factors%20associated%20with%20alexithymia%20in%20adults%20with%20epilepsy&offset=0&pcAvailability=true
Publisher
EPILEPSY BEHAVIOR
Location
미국
Language
영어
ISSN
1525-5050
Citation Volume
114
Citation Number
part.A
Citation Start Page
107582
Citation End Page
107582
Appears in Collections:
Medicine > Medicine
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