Assessing the diagnostic performance of thyroid biopsy with recommendations for appropriate interpretation
- Abstract
- Purpose: The diagnostic performance of thyroid biopsy is influenced by several factors, including differences in the Bethesda categorization for malignancy, the inclusion or exclusion of non-diagnostic results, the definition used for the final diagnosis, and the definition of an inconclusive diagnosis. The purpose of this study was to provide an understanding of the factors influencing the diagnostic performance of thyroid biopsy.
Methods: We collected data retrospectively between January and December 2013 from a cohort of 6,762 thyroid nodules from 6,493 consecutive patients who underwent biopsy. In total, 4,822 nodules from 4,553 patients were included. We calculated the biopsy sensitivity according to the inclusion of different Bethesda categories in the numerator and the exclusion of non-diagnostic results, as well as the diagnostic accuracy according to different definitions of a benign diagnosis. We obtained the conclusive and inconclusive diagnosis rates.
Results: The sensitivity increased when more Bethesda categories were included in the numerator and when non-diagnostic results were excluded. When a benign thyroid nodule diagnosis was defined as benign findings on surgical resection, concordant benign results on at least two occasions, or an initial benign biopsy result and follow-up for more than 12 months, the accuracy was higher than when the diagnosis was based on surgical resection alone (91.1% vs. 68.7%). A higher conclusive diagnosis rate was obtained when Bethesda categories I and III were considered inconclusive than when Bethesda categories I, III and IV were considered inconclusive (78.3% vs. 72.8%, P<0.001).
Conclusion: Understanding the concepts presented herein is important in order to appropriately interpret the diagnostic performance of thyroid biopsy.
- Author(s)
- 나동규; 백정환; 서종현; 성태연; 송동은; 송영기; 이정현; 정찬권; 하수민
- Issued Date
- 2021
- Type
- Article
- Keyword
- Biopsy; Diagnosis; Original; Thyroid neoplasms; Thyroid nodule; Ultrasonography; 방사선과학
- DOI
- 10.14366/usg.19099
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7876
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9770190&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Assessing%20the%20diagnostic%20performance%20of%20thyroid%20biopsy%20with%20recommendations%20for%20appropriate%20interpretation&offset=0&pcAvailability=true
- Publisher
- ULTRASONOGRAPHY
- Location
- 대한민국
- Language
- 영어
- ISSN
- 2288-5919
- Citation Volume
- 40
- Citation Number
- 2
- Citation Start Page
- 228
- Citation End Page
- 236
-
Appears in Collections:
- Medicine > Medicine
- Authorize & License
-
- Files in This Item:
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.