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The 2020 revision of the guidelines for the management of myeloproliferative neoplasms

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Abstract
In 2016, the World Health Organization revised the diagnostic criteria for myeloproliferative neoplasms (MPNs) based on the discovery of disease-driving genetic aberrations and extensive analysis of the clinical characteristics of patients with MPNs. Recent studies have suggested that additional somatic mutations have a clinical impact on the prognosis of patients harboring these genetic abnormalities. Treatment strategies have also advanced with the introduction of JAK inhibitors, one of which has been approved for the treatment of patients with myelofibrosis and those with hydroxyurea-resistant or intolerant polycythemia vera. Recently developed drugs aim to elicit hematologic responses, as well as symptomatic and molecular responses, and the response criteria were refined accordingly. Based on these changes, we have revised the guidelines and present the diagnosis, treatment, and risk stratification of MPNs encountered in Korea.
Author(s)
김민경김성용김수정김호영김희진남승현문영철박지니방수미배성화엄기성원종호정철원최철원홍준식장성수
Issued Date
2021
Type
Article
Keyword
essentialPolycythemia veraPractice guidelinePrimary myelofibrosisThrombocythemia
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7886
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_kiss_primary_3845876&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,The%202020%20revision%20of%20the%20guidelines%20for%20the%20management%20of%20myeloproliferative%20neoplasms&offset=0&pcAvailability=true
Publisher
KOREAN JOURNAL OF INTERNAL MEDICINE
Location
대한민국
Language
영어
ISSN
1226-3303
Citation Volume
36
Citation Number
1
Citation Start Page
45
Citation End Page
62
Appears in Collections:
Medicine > Medicine
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