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Frequency of putative enteric zoster diagnosed using saliva samples in patients with abdominal pain: a prospective study

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Abstract
Background

Varicella-zoster virus (VZV) infects and establishes latency in neurons in the ganglia of the cranial nerve, dorsal root and enteric ganglia. VZV reactivation in enteric neurons (enteric zoster) can cause non-specific abdominal pain and/or serious gastrointestinal dysfunction without cutaneous manifestations. Detection of VZV DNA in saliva may be useful for identifying enteric zoster. We evaluated the frequency of putative enteric zoster based on the presence of salivary VZV DNA in patients with acute abdominal pain.

Methods

Adult patients who visited the emergency room due to moderate to severe acute abdominal pain were prospectively enrolled at a tertiary hospital between May 2019 and November 2019. Abdominopelvic computed tomography (APCT) was performed in all patients. We also evaluated the presence of salivary VZV DNA in patients with confirmed coronavirus disease-19 (COVID-19) who were under stressful conditions. Saliva samples were collected from all studied patients. Enteric zoster was suspected based on the presence of salivary VZV DNA, detected using real-time polymerase chain reaction (PCR).

Results

Fifty patients with moderate to severe abdominal pain were enrolled. Five of 50 patients exhibited positive VZV-DNA PCR results. APCT revealed that among these five patients, two had pancreatic head cancer, two had small bowel obstruction after intra-abdominal surgery, and one had no remarkable findings. However, all 14 patients with COVID-19 showed negative salivary VZV-DNA PCR results.

Conclusions

Approximately 10% of patients with moderate to severe acute abdominal pain showed positivity for salivary VZV DNA. Further studies are warranted on whether antiviral therapy based on salivary VZV-DNA PCR results may relieve abdominal pain in the studied patient population.
Author(s)
권지수김민재김성한김양수김원영김지연라상현이상오이현정정용필정지원차혜희최상호
Issued Date
2021
Type
Article
Keyword
enteric zostersalivaVaricella-zoster virus
DOI
10.1080/23744235.2021.1908593
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7889
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_pubmed_primary_33830871&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Frequency%20of%20putative%20enteric%20zoster%20diagnosed%20using%20saliva%20samples%20in%20patients%20with%20abdominal%20pain:%20a%20prospective%20study&offset=0&pcAvailability=true
Publisher
INFECTIOUS DISEASES
Location
스웨덴
Language
한국어
ISSN
2374-4235
Citation Volume
53
Citation Number
9
Citation Start Page
713
Citation End Page
718
Appears in Collections:
Medicine > Medicine
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