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Role of Antimicrobial Susceptibility Testing before First-Line Treatment Containing Clarithromycin for Helicobacter pylori Eradication in the Clinical Setting

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Abstract
Background: Checking Helicobacter pylori susceptibility tests in the clinical setting before first-line treatment is considered difficult. We compared susceptibility-guided therapy (SGT) with empirical therapy (ET) as a first-line treatment containing clarithromycin and investigated the eradication rate using antimicrobial susceptibility testing (AST). Methods: 257 patients with H. pylori infection, with AST, performed before the eradication of clarithromycin-containing regimens were enrolled and divided into two groups: the SGT and ET groups. Results: Eradication rates in the SGT and ET groups were 85.4% and 58.4% (P < 0.01), respectively. In triple therapy (TT), eradication rates of the SGT and ET groups were 85.1% and 56.6% (P < 0.01), respectively. In sequential therapy (SET), eradication rates of the SGT and ET groups were 86.2% and 65.6% (P = 0.06), respectively. According to AST, TT had an eradication rate of 84.6% with strains susceptible to clarithromycin and amoxicillin and 11.1% with strains resistant to both. SET had an eradication rate of 89.5% with strains susceptible to clarithromycin, amoxicillin, and metronidazole, whereas it was 0% with strains resistant to clarithromycin and metronidazole. Conclusions: SGT as first-line treatment improved eradication rates of TT and SET by 28.5 (P < 0.01) and 20.6 (P = 0.06) percent points, respectively, compared with ET.
Author(s)
강석인김유리안지용정훈용김나영나희경이정훈정기욱김도훈최기돈송호준이진혁
Issued Date
2021
Type
Article
Keyword
clarithromycinHelicobacter infectionHelicobacter pylorimicrobial drug resistancemicrobial sensitivity tests
DOI
10.3390/antibiotics10020214
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7895
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_594a5ddddf1f4cfa9bcdb37c23da0b4c&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Role%20of%20Antimicrobial%20Susceptibility%20Testing%20before%20First-Line%20Treatment%20Containing%20Clarithromycin%20for%20Helicobacter%20pylori%20Eradication%20in%20the%20Clinical%20Setting&amp;offset=0&amp;pcAvailability=true
Publisher
ANTIBIOTICS-BASEL
Location
스위스
Language
영어
ISSN
2079-6382
Citation Volume
10
Citation Number
2
Citation Start Page
214
Citation End Page
214
Appears in Collections:
Medicine > Medicine
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