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Impact of 1-Hour Bundle Achievement in Septic Shock

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Abstract
This study aimed to address the impact of 1-hr bundle achievement on outcomes in septic shock patients. Secondary analysis of multicenter prospectively collected data on septic shock patients who had undergone protocolized resuscitation bundle therapy at emergency departments was conducted. In-hospital mortality according to 1-h bundle achievement was compared using multivariable logistic regression analysis. Patients were also divided into 3 groups according to the time of bundle achievement and outcomes were compared to examine the difference in outcome for each group over time: group 1 (<= 1 h reference), group 2 (1-3 h) and group 3 (3-6 h). In total, 1612 patients with septic shock were included. The 1-h bundle was achieved in 461 (28.6%) patients. The group that achieved the 1-h bundle did not show a significant difference in in-hospital mortality compared to the group that did not achieve the 1-h bundle on multivariable logistic regression analysis (1 h) (odds ratio = 0.74, p = 0.091). However, 3- and 6- h bundle achievements showed significantly lower odds ratios of in-hospital mortality compared to the group that did not achieve the bundle (3 h, 6 h, odds ratio = 0.604 and 0.458, respectively). There was no significant difference in in-hospital mortality over time for group 2 and 3 compared to that of group 1. One-hour bundle achievement was not associated with improved outcomes in septic shock patients. These data suggest that further investigation into the clinical implications of 1-h bundle achievement in patients with septic shock is warranted.
Author(s)
김원영유승목Byuk Sung KoDonghee SonGil Joon SuhHan Sung ChoiHyunggoo KangKyuseok KimSung Phil ChungSung-Hyuk ChoiTae Gun ShinTae Ho LimWoon Yong KwonYoo Seok ParkYou Hwan Jo
Issued Date
2021
Type
Article
Keyword
1-h bundleemergency departmentmortalityoutcomesepsisseptic shock
DOI
10.3390/jcm10030527
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7901
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_53e6b7e3a9b14fdcb51c12265fb0dd0c&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Impact%20of%201-Hour%20Bundle%20Achievement%20in%20Septic%20Shock&amp;offset=0&amp;pcAvailability=true
Publisher
Journal of clinical medicine
Location
미국
Language
영어
ISSN
2077-0383
Citation Volume
10
Citation Number
3
Citation Start Page
527
Citation End Page
527
Appears in Collections:
Medicine > Medicine
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