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EPHA3 Contributes to Epigenetic Suppression of PTEN in Radioresistant Head and Neck Cancer

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Abstract
EPHA3, a member of the EPH family, is overexpressed in various cancers. We demonstrated previously that EPHA3 is associated with radiation resistance in head and neck cancer via the PTEN/Akt/EMT pathway; the inhibition of EPHA3 significantly enhances the efficacy of radiotherapy in vitro and in vivo. In this study, we investigated the mechanisms of PTEN regulation through EPHA3-related signaling. Increased DNA methyltransferase 1 (DNMT1) and enhancer of zeste homolog 2 (EZH2) levels, along with increased histone H3 lysine 27 trimethylation (H3K27me3) levels, correlated with decreased levels of PTEN in radioresistant head and neck cancer cells. Furthermore, PTEN is regulated in two ways: DNMT1-mediated DNA methylation, and EZH2-mediated histone methylation through EPHA3/C-myc signaling. Our results suggest that EPHA3 could display a novel regulatory mechanism for the epigenetic regulation of PTEN in radioresistant head and neck cancer cells.
Author(s)
김송희강병철성다슬이원혁안재희제형욱차희정장효원김상윤김승후한명월
Issued Date
2021
Type
Article
Keyword
head and neck cancerradioresistancePTENEPHA3C-mycDNMT1EZH2DNA
DOI
10.3390/biom11040599
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7903
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_d35491c7cd4a49b6a1e246e1abf306dd&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,EPHA3%20Contributes%20to%20Epigenetic%20Suppression%20of%20PTEN%20in%20Radioresistant%20Head%20and%20Neck%20Cancer&offset=0&pcAvailability=true
Publisher
BIOMOLECULES
Location
스위스
Language
영어
ISSN
2218-273X
Citation Volume
11
Citation Number
4
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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