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A prognostic index for extranodal marginal-zone lymphoma based on the mucosa-associated lymphoid tissue International Prognostic Index and serum β2-microglobulin levels

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Abstract
The mucosa-associated lymphoid tissue (MALT) International Prognostic Index (IPI) was recently proposed as a prognostic index for patients with MALT lymphoma. We aimed to investigate the prognostic value of the serum β2-microglobulin level in the context of MALT-IPI, and we proposed a new prognostic index. Survival outcomes were analysed with regard to β2-microglobulin level, MALT-IPI, and the new prognostic index in MALT lymphoma patients (n?=?571). The validity of the new prognostic index was assessed using an independent cohort (n?=?216). Patients with high β2-microglobulin levels had significantly worse progression-free survival (PFS) and overall survival (OS) outcomes. A high β2-microglobulin level was independently associated with poor PFS and OS. β2-microglobulin levels further stratified patients in the MALT-IPI intermediate-risk group in terms of PFS and OS. A new prognostic index based on the MALT-IPI and the β2-microglobulin level, MALT-IPI-B, was proposed. The MALT-IPI-B was able to stratify patients into subgroups having distinct PFS and OS outcomes in both the training and validation cohorts. MALT-IPI-B enabled the identification of patients with poor survival outcomes who were classified into the intermediate-risk group by the MALT-IPI. In conclusion, this new β2-microglobulin-based prognostic index may have the specific advantage of identifying high-risk patients who may require systemic treatment.
Author(s)
강은희김신김형돈류진숙박정선박찬식방경혜서철원오성용윤덕현이경민이상욱정혜현조형우허주영
Issued Date
2021
Type
Article
Keyword
mucosa-associated lymphoid tissue International Prognostic Indexmucosa-associated lymphoid tissue lymphomaprognostic indexβ2-microglobulin
DOI
10.1111/bjh.17222
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7905
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2463098742&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,A%20prognostic%20index%20for%20extranodal%20marginal-zone%20lymphoma%20based%20on%20the%20mucosa-associated%20lymphoid%20tissue%20International%20Prognostic%20Index%20and%20serum%20%CE%B22-microglobulin%20levels&offset=0&pcAvailability=true
Publisher
BRITISH JOURNAL OF HAEMATOLOGY
Location
대한민국
Language
영어
ISSN
0007-1048
Citation Volume
193
Citation Number
2
Citation Start Page
307
Citation End Page
315
Appears in Collections:
Medicine > Medicine
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