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Treatment Outcome and Risk Factors Associated with Diffuse Axonal Injury in Patients with Moderate to Severe Head Injury

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Abstract
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Aim: Diffuse axonal injury (DAI) is an important determining factor of morbidity and mortality after traumatic brain injury (TBI). However, its clinical outcome remains a subject of debate.

Material and methods: A total of 992 TBI patients visited our hospital between 2011 and 2016. Thirty-seven patients diagnosed with DAI were enrolled in this study and stratified by DAI stage: stage I, 20 patients (54.1%); stage II, 4 patients (10.8%); and stage III, 13 patients (35.1%).

Results: The mean age and the median follow-up period were 45.43 years and 13 months, respectively. Patient demographic data and clinical findings on admission showed no differences according to DAI stage, except for the revised trauma score (RTS) (p = 0.026). In univariate analysis, stages I and II vs. III (p = 0.001) and stages I vs. II and III (p = 0.019), transfusion within 24 hours of visit (p = 0.033), shock or cardiac arrest (p = 0.006), traumatic subarachnoid hemorrhage (T-SAH) (p = 0.011), and subdural hematoma (SDH) (p = 0.009) were significantly correlated with Glasgow outcome score (GOS). In multivariate analysis, DAI stage I and II vs. III (p = 0.005) and SDH (p = 0.040) were significant.

Conclusion: Clinically, stage II was more correlated with stage I, rather than stage III. Stage III showed a much poorer outcome compared to stages I and II. Magnetic resonance imaging (MRI) should be promptly performed in all TBI patients when a patient's level of consciousness and cranial computed tomography (CT) does not match, as there is a possibility of stage III DAI.
Author(s)
김모이네전상용노성우홍석경이승주
Issued Date
2021
Type
Article
Keyword
Craniocerebral Trauma - complicationsCraniocerebral Trauma - diagnostic imagingCraniocerebral Trauma - therapyDiffuse Axonal Injury - diagnostic imagingHumansMagnetic Resonance ImagingRisk FactorsTreatment Outcome
DOI
10.5137/1019-5149.JTN.28132-19.4
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7937
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_crossref_primary_10_5137_1019_5149_JTN_28132_19_4&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Treatment%20Outcome%20and%20Risk%20Factors%20Associated%20with%20Diffuse%20Axonal%20Injury%20in%20Patients%20with%20Moderate%20to%20Severe%20Head%20Injury&offset=0&pcAvailability=true
Publisher
Turkish Neurosurgery
Location
터키
Language
한국어
ISSN
1019-5149
Citation Volume
1
Citation Number
7
Citation Start Page
1172
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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