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Independent Risk Factors for Sepsis-Associated Cardiac Arrest in Patients with Septic Shock

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Abstract
The clinical characteristics and laboratory values of patients with septic shock who experience in-hospital cardiac arrest (IHCA) have not been well studied. This study aimed to evaluate the prevalence of IHCA after admission into the emergency department and to identify the factors that increase the risk of IHCA in septic shock patients. This observational cohort study used a prospective registry of septic shock patients and was conducted at the emergency department of a university-affiliated hospital. The data of 887 adult (age >= 18 years) septic shock (defined using the Sepsis-3 criteria) patients who were treated with a protocol-driven resuscitation bundle therapy and were admitted to the intensive care unit between January 2010 and September 2018 were analyzed. The primary endpoint was the occurrence of sepsis-associated cardiac arrest. The patient mean age was 65 years, and 61.8% were men. Sepsis-associated cardiac arrest occurred in 25.3% of patients (n = 224). The 28-day survival rate after cardiac arrest was 6.7%. Multivariate logistic regression identified chronic pulmonary disease (odds ratio (OR) 2.06), hypertension (OR 0.48), unknown infection source (OR 1.82), a hepatobiliary infection source (OR 0.25), C-reactive protein (OR 1.03), and serum lactate level 6 h from shock (OR 1.34). Considering the high mortality rate of sepsis-associated cardiac arrest after cardiopulmonary resuscitation, appropriate monitoring is required in septic shock patients with major risk factors for IHCA.
Author(s)
김원영김윤정유승목Won Soek Yang
Issued Date
2021
Type
Article
Keyword
cardiac arrestmortalitysepsisseptic shock
DOI
10.3390/ijerph18094971
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7947
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_752a31ccf0c24d8886d9e460f1965fb9&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Independent%20Risk%20Factors%20for%20Sepsis-Associated%20Cardiac%20Arrest%20in%20Patients%20with%20Septic%20Shock&offset=0&pcAvailability=true
Publisher
International Journal of Environmental Research and Public Health
Location
미국
Language
영어
ISSN
1660-4601
Citation Volume
18
Citation Number
9
Citation Start Page
4971
Citation End Page
4971
Appears in Collections:
Medicine > Medicine
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