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Current Status and Future Perspectives of Perioperative Therapy for Resectable Biliary Tract Cancer: A Multidisciplinary Review

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Abstract
Simple Summary

For decades, there has been no globally accepted neoadjuvant or adjuvant therapy in resectable biliary tract cancer. Based on the results of the BILCAP trial, adjuvant capecitabine has been widely regarded as standard adjuvant therapy. Focusing on the management of resectable biliary tract cancer, this article reviews each therapeutic strategy including surgery, chemotherapy and radiotherapy, and summarises published and ongoing clinical trials of neoadjuvant and adjuvant therapy.

Biliary tract cancers (BTCs) are a group of aggressive malignancies that arise from the bile duct and gallbladder. BTCs include intrahepatic cholangiocarcinoma (IH-CCA), extrahepatic cholangiocarcinoma (EH-CCA), and gallbladder cancer (GBCA). BTCs are highly heterogeneous cancers in terms of anatomical, clinical, and pathological characteristics. Until recently, the treatment of resectable BTC, including surgery, adjuvant chemotherapy, and radiation therapy, has largely been based on institutional practice guidelines and evidence from small retrospective studies. Recently, several large randomized prospective trials have been published, and there are ongoing randomized trials for resectable BTC. In this article, we review prior and recently updated evidence regarding surgery, adjuvant and neoadjuvant chemotherapy, and adjuvant radiation therapy for patients with resectable BTC.
Author(s)
김규표류백렬박준오박진홍송기병신상현유창훈이우형이재훈정재호황대욱
Issued Date
2021
Type
Article
Keyword
adjuvant chemotherapybiliary tract cancercholangiocarcinomagallbladder cancerradiation therapyReviewsurgery
DOI
10.3390/cancers13071647
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7960
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_12f52e1babb845e9959e22c06a67b9c8&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Current%20Status%20and%20Future%20Perspectives%20of%20Perioperative%20Therapy%20for%20Resectable%20Biliary%20Tract%20Cancer:%20A%20Multidisciplinary%20Review&offset=0&pcAvailability=true
Publisher
CANCERS
Location
스위스
Language
영어
ISSN
2072-6694
Citation Volume
13
Citation Number
7
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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