Current Status and Future Perspectives of Perioperative Therapy for Resectable Biliary Tract Cancer: A Multidisciplinary Review
- Abstract
- Simple Summary
For decades, there has been no globally accepted neoadjuvant or adjuvant therapy in resectable biliary tract cancer. Based on the results of the BILCAP trial, adjuvant capecitabine has been widely regarded as standard adjuvant therapy. Focusing on the management of resectable biliary tract cancer, this article reviews each therapeutic strategy including surgery, chemotherapy and radiotherapy, and summarises published and ongoing clinical trials of neoadjuvant and adjuvant therapy.
Biliary tract cancers (BTCs) are a group of aggressive malignancies that arise from the bile duct and gallbladder. BTCs include intrahepatic cholangiocarcinoma (IH-CCA), extrahepatic cholangiocarcinoma (EH-CCA), and gallbladder cancer (GBCA). BTCs are highly heterogeneous cancers in terms of anatomical, clinical, and pathological characteristics. Until recently, the treatment of resectable BTC, including surgery, adjuvant chemotherapy, and radiation therapy, has largely been based on institutional practice guidelines and evidence from small retrospective studies. Recently, several large randomized prospective trials have been published, and there are ongoing randomized trials for resectable BTC. In this article, we review prior and recently updated evidence regarding surgery, adjuvant and neoadjuvant chemotherapy, and adjuvant radiation therapy for patients with resectable BTC.
- Author(s)
- 김규표; 류백렬; 박준오; 박진홍; 송기병; 신상현; 유창훈; 이우형; 이재훈; 정재호; 황대욱
- Issued Date
- 2021
- Type
- Article
- Keyword
- adjuvant chemotherapy; biliary tract cancer; cholangiocarcinoma; gallbladder cancer; radiation therapy; Review; surgery
- DOI
- 10.3390/cancers13071647
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7960
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_12f52e1babb845e9959e22c06a67b9c8&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Current%20Status%20and%20Future%20Perspectives%20of%20Perioperative%20Therapy%20for%20Resectable%20Biliary%20Tract%20Cancer:%20A%20Multidisciplinary%20Review&offset=0&pcAvailability=true
- Publisher
- CANCERS
- Location
- 스위스
- Language
- 영어
- ISSN
- 2072-6694
- Citation Volume
- 13
- Citation Number
- 7
- Citation Start Page
- 0
- Citation End Page
- 0
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- Medicine > Medicine
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