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Systemic Treatment of Advanced Gastroenteropancreatic Neuroendocrine Tumors in Korea: Literature Review and Expert Opinion

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Abstract
Neuroendocrine tumors (NETs) are a group of malignancies arising from neuroendocrine cells and frequently originate in the gastrointestinal tract and pancreas. Although curative resection is the main treatment for localized disease, systemic therapy is needed for relapsed or metastatic/unresectable gastroenteropancreatic NETs (GEP-NETs). Although there are several NET treatment guidelines from various countries, the geographical discrepancies between patient clinical characteristics, the regulatory approval status for therapeutic agents, and medical practices necessitate specific guidelines for Korean patients. We here provide a consensus review of the diagnosis, staging and systemic treatment of Korean GEP-NET patients. Systemic therapy options and the current Korean expert consensus on these treatments, including somatostatin analogs, targeted therapies such as everolimus and sunitinib, peptide receptor radionuclide treatments, and cytotoxic chemotherapies are addressed.
Author(s)
김승태류백렬배우균오도연오충렬유창훈이명아최혜진
Issued Date
2021
Type
Article
Keyword
Neuroendocrine tumorLanreotideOctreotideEverolimusSunitinibPeptide receptor radionuclide therapyCapecitabineTemozolomide
DOI
10.4143/crt.2020.1233
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7966
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9774538&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Systemic%20Treatment%20of%20Advanced%20Gastroenteropancreatic%20Neuroendocrine%20Tumors%20in%20Korea:%20Literature%20Review%20and%20Expert%20Opinion&offset=0&pcAvailability=true
Publisher
CANCER RESEARCH AND TREATMENT
Location
대한민국
Language
영어
ISSN
1598-2998
Citation Volume
53
Citation Number
2
Citation Start Page
291
Citation End Page
300
Appears in Collections:
Medicine > Medicine
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